Epistatic interactions and drug response Journal Article

  


Authors: Weigelt, B.; Reis-Filho, J. S.
Article Title: Epistatic interactions and drug response
Abstract: The advent of massively parallel sequencing has allowed for an unprecedented genetic characterization of cancers, which has revealed not only the complexity of cancer genomes, but also the fact that tumours from the same anatomical site or even of the same histological and/or molecular subtype display distinct constellations of somatic genetic aberrations. Epistatic interactions (ie the interplay between genetic aberrations) are likely to play pivotal roles not only in terms of tumourigenesis and disease progression, but also in response to therapeutic interventions. In this review, we discuss the challenges posed by the complexity of tumour genomes and epistatic interactions, and approaches for harnessing the wealth of genetic information on human cancers for the implementation of precision medicine. Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Keywords: mutation; genotype; targeted therapy; genetic interaction; epistasis; massively parallel sequencing; precision medicine
Journal Title: Journal of Pathology
Volume: 232
Issue: 2
ISSN: 0022-3417
Publisher: Wiley Blackwell  
Date Published: 2014-01-01
Start Page: 255
End Page: 263
Language: English
DOI: 10.1002/path.4265
PROVIDER: scopus
PUBMED: 24105606
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84890282746&partnerID=40&md5=f004243a4d937f50ad6c5d66a21383f0
Notes: Cited By (since 1996):1 -- Export Date: 2 January 2014 -- CODEN: JPTLA -- Source: Scopus
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MSK Authors
  1. Britta Weigelt
    632 Weigelt
  2. Jorge Sergio Reis-Filho
    639 Reis-Filho
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