Improving outcomes in high-risk prostate cancer with radiotherapy Journal Article

   


Authors: Polkinghorn, W. R.; Zelefsky, M. J.
Article Title: Improving outcomes in high-risk prostate cancer with radiotherapy
Abstract: There have been significant improvements in the radiotherapeutic management of patients with high risk prostate cancer. Randomized trials have clearly demonstrated improved outcomes with the combination of radiotherapy in conjunction with androgen deprivation. While these trials have utilized low doses of radiotherapy in the range of 70. Gy, recent studies have suggested that significant benefits of combined androgen deprivation therapy with dose escalated radiotherapy are also observed. The use of high radiation dose levels in the setting of high risk prostate cancer is important, and strategies which combine external beam radiotherapy with a brachytherapy boost may provide an opportunity for even greater intensification of the radiation dose to the prostate target. Systemic therapies, second generation anti-androgen therapy and novel targeted agents integrated with radiotherapy will open up new vistas and challenges for further improved outcomes in patients with high-risk disease. © 2013 Greater Poland Cancer Centre.
Keywords: treatment outcome; androgen; review; intensity modulated radiation therapy; cancer risk; systemic therapy; adjuvant therapy; cancer adjuvant therapy; cancer radiotherapy; comparative study; radiation dose; prostate specific antigen; dna repair; multiple cycle treatment; distant metastasis; high risk patient; docetaxel; prostate cancer; gleason score; leuprorelin; prostate biopsy; brachytherapy; androgen receptor; external beam radiotherapy; abiraterone acetate; bicalutamide; computer assisted radiotherapy; androgen deprivation therapy; recurrence free survival; androgen-deprivation therapy; randomized controlled trial (topic); external beam radiation therapy; high-risk prostate cancer; distant metastasis free survival; enzalutamide; antiandrogen therapy; human; anti-androgen agents
Journal Title: Reports of Practical Oncology and Radiotherapy
Volume: 18
Issue: 6
ISSN: 1507-1367
Publisher: Elsevier Inc.  
Date Published: 2013-11-01
Start Page: 333
End Page: 337
Language: English
DOI: 10.1016/j.rpor.2013.10.006
PROVIDER: scopus
PMCID: PMC3863285
PUBMED: 24416574
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84888306427&partnerID=40&md5=392c28ea25f1e1ea3cdf54f9012f3e5d
Notes: Export Date: 2 January 2014 -- CODEN: RPORA -- Source: Scopus
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MSK Authors
  1. Michael J Zelefsky
    754 Zelefsky
  2. William Reilly Polkinghorn
    24 Polkinghorn
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