Genetically engineered donor T cells to optimize graft-versus-tumor effects across MHC barriers Journal Article

   


Authors: Ghosh, A.; Holland, A. M.; van den Brink, M. R. M.
Article Title: Genetically engineered donor T cells to optimize graft-versus-tumor effects across MHC barriers
Abstract: Hematopoietic stem cell transplantation has been used for more than 50 years to combat hematologic malignancies. In addition to being the first stem cell therapy, transplantation has provided evidence for the potent anti-tumor effects of T cells. Facilitating T-cell-based immunity against malignancies requires a careful balancing act between generating a robust response and avoiding off-target killing of healthy tissues, which is difficult to accomplish using bulk donor T cells. To address these issues, several approaches have been developed, drawing on basic T-cell biology, to potentiate graft-versus-tumor activity while avoiding graft-versus-host disease. Current strategies for anti-tumor cell therapies include: (i) selecting optimal T cells for transfer; (ii) engineering T cells to possess enhanced effector functions; and (iii) generating T-cell precursors that complete development after adoptive transfer. In this review, we assess the current state of the art in T-lineage cell therapy to treat malignancies in the context of allogeneic hematopoietic stem cell transplantation. © 2013 John Wiley & Sons A/S.
Keywords: gvhd; plzf; trail; gvt; allo-hsct; precursor t cells
Journal Title: Immunological Reviews
Volume: 257
Issue: 1
ISSN: 0105-2896
Publisher: Wiley Blackwell  
Date Published: 2014-01-01
Start Page: 226
End Page: 236
Language: English
DOI: 10.1111/imr.12142
PROVIDER: scopus
PMCID: PMC3874121
PUBMED: 24329800
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84890236232&partnerID=40&md5=ff7508e34b0b67630c26fe6552e4b994
Notes: Cited By (since 1996):1 -- Export Date: 2 January 2014 -- CODEN: IMRED -- Source: Scopus
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MSK Authors
  1. Marcel R M Van Den Brink
    616 Van Den Brink
  2. Arnab Ghosh
    64 Ghosh
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