Prevalence of HOXB13 mutation in a population of Ashkenazi Jewish men treated for prostate cancer Journal Article

Authors: Alanee, S.; Shah, S.; Vijai, J.; Schrader, K.; Hamilton, R.; Rau-Murthy, R.; Sarrel, K.; Manschreck, C.; Eastham, J.; Offit, K.
Article Title: Prevalence of HOXB13 mutation in a population of Ashkenazi Jewish men treated for prostate cancer
Abstract: We performed a retrospective analysis of germline DNA samples from Ashkenazi Jewish men and a comparison group of non-Ashkenazi men treated for prostate cancer at our institution to determine the prevalence of HOXB13 G84E mutation in prostate cancer patients of Ashkenazi Jewish heritage, an ethnic group common to the New York City area. Patients were genotyped for G84E using a TaqMan assay (Applied Biosystems). Positive cases were confirmed using Sanger sequencing. Median age at prostate cancer diagnosis was 68 years for 889 Ashkenazi Jewish patients, 64 years for 920 non-Ashkenazi Jewish patients. The median follow up was 9 years for Ashkenazi Jewish patients and 8.8 years for non-Ashkenazi Jewish patients. Only 4 patients were found to be heterozygous carriers of G84E. They were all of non-Ashkenazi Jewish ancestry and were diagnosed at 70, 66, 78, and 49 years of age. Two of them presented with high-risk prostate cancer. The prevalence of G84E in the non-Ashkenazi sample was 0.4 %. HOXB13 G84E mutation was not observed in prostate cancer patients of Ashkenazi Jewish ancestry treated at our institution. Screening for G84E, therefore, may be unnecessary in Ashkenazi Jewish men if these results are validated by other studies. © 2013 Springer Science+Business Media Dordrecht.
Keywords: adult; controlled study; aged; major clinical study; missense mutation; follow up; gene; genotype; gene frequency; heterozygote; retrospective study; high risk patient; risk; prostate cancer; prostatic neoplasms; dna; dna determination; jew; germline mutation; human; male; priority journal; article; hoxb13 gene
Journal Title: Familial Cancer
Volume: 12
Issue: 4
ISSN: 1389-9600
Publisher: Springer  
Date Published: 2013-12-01
Start Page: 597
End Page: 600
Language: English
DOI: 10.1007/s10689-013-9618-y
PROVIDER: scopus
PUBMED: 23475555
PMCID: PMC5073797
Notes: Export Date: 2 January 2014 -- CODEN: FCAAA -- Source: Scopus
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MSK Authors
  1. Kenneth Offit
    538 Offit
  2. James Eastham
    435 Eastham
  3. Vijai Joseph
    126 Joseph
  4. Sohela Shah
    15 Shah
  5. Shaheen Riadh Alanee
    11 Alanee
  6. Kara Lindsay Sarrel
    7 Sarrel