A deathly DNase activity for dicer Journal Article
| Authors: | Okamura, K.; Lai, E. C. |
| Article Title: | A deathly DNase activity for dicer |
| Abstract: | Recently reporting in Science, Nakagawa et al. describe an unexpected role for Dicer in chromosome fragmentation during apoptosis in C. elegans. They find that cleavage of DCR-1 by the caspase CED-3 redirects its regulatory activity, by destroying its dsRNase activity while activating an intrinsic DNase activity. © 2010 Elsevier Inc. |
| Keywords: | unclassified drug; nonhuman; dna damage; apoptosis; microrna; protein protein interaction; small interfering rna; enzyme activation; enzyme activity; caspase; rna binding protein; enzyme regulation; short survey; caenorhabditis elegans; endonuclease; dicer; dicer 1; ribonuclease iii; dna degradation; deoxyribonuclease; dna rna hybridization; enzyme metabolism; caspase activated deoxyribonuclease; protein ced 3; protein dff45; chromosome damage |
| Journal Title: | Developmental Cell |
| Volume: | 18 |
| Issue: | 5 |
| ISSN: | 1534-5807 |
| Publisher: | Cell Press |
| Date Published: | 2010-05-01 |
| Start Page: | 692 |
| End Page: | 694 |
| Language: | English |
| DOI: | 10.1016/j.devcel.2010.05.004 |
| PROVIDER: | scopus |
| PUBMED: | 20493803 |
| PMCID: | PMC4583219 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: DCEEB" - "Source: Scopus" |
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