Anaplastic thyroid cancer, tumorigenesis and therapy Journal Article
| Authors: | O'neill, J. P.; Power, D.; Condron, C.; Bouchier-Hayes, D.; Walsh, M. |
| Article Title: | Anaplastic thyroid cancer, tumorigenesis and therapy |
| Abstract: | Background: Anaplastic thyroid cancer (ATC) is a fatal endocrine malignancy. Current therapy fails to significantly improve survival. Recent insights into thyroid tumorigenesis, post-malignant dedifferentiation and mode of metastatic activity offer new therapeutic strategies. Methods: An extensive literature search of Medline and Pubmed was conducted to include all published reports on ATC. Secondary articles were identified from key paper reference listings. Conclusions: Significant progress, in the last 5 years, has been made outlining thyroid tumorigenesis and the progression to anaplasia. Continued identification and development of drug therapies is required to counter specific molecular targets responsible for the post-malignant dedifferentiation process and ultimately the fatal neoplastic phenotype. © 2009 Royal Academy of Medicine in Ireland. |
| Keywords: | protein kinase b; vasculotropin; gene mutation; disease course; review; sorafenib; bevacizumab; doxorubicin; nonhuman; drug targeting; gemcitabine; paclitaxel; chemotherapy; enzyme inhibition; radiotherapy; epidermal growth factor receptor; cetuximab; phosphatidylinositol 3 kinase; protein p53; uvomorulin; carcinogenesis; irinotecan; oncogene; patient care; drug research; iodine 131; surgery; medline; medical literature; ras protein; thyroid cancer; external beam radiotherapy; navelbine; cyclin d1; beta catenin; protein ret; b raf kinase; multidrug resistance; cyclin e; thyroid transcription factor 1; thyroid surgery; multidrug resistance protein 1; anaplastic thyroid cancer; post-malignant dedifferentiation; undifferentiation; 6 [4 (4 ethyl 1 piperazinylmethyl)phenyl] 4 (alpha methylbenzylamino) 7h pyrrolo[2,3 d]pyrimidine; sodium iodide symporter; transcription factor pax8; thyroid scintiscanning |
| Journal Title: | Irish Journal of Medical Science |
| Volume: | 179 |
| Issue: | 1 |
| ISSN: | 0021-1265 |
| Publisher: | Springer London |
| Date Published: | 2010-03-01 |
| Start Page: | 9 |
| End Page: | 15 |
| Language: | English |
| DOI: | 10.1007/s11845-009-0364-y |
| PROVIDER: | scopus |
| PUBMED: | 19662494 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: IJMSA" - "Source: Scopus" |
