Splenectomy to treat splenic lesions: An analysis of 148 cases at a cancer center Journal Article


Authors: Pugalenthi, A.; Bradley, C.; Gonen, M.; Do, K. G.; Strong, V.; Jarnagin, W.; Coit, D.; Kingham, T. P.
Article Title: Splenectomy to treat splenic lesions: An analysis of 148 cases at a cancer center
Abstract: Background and Objectives Solid and cystic splenic masses discovered on imaging studies often pose diagnostic and management dilemmas. This study analyses a large series of splenectomies to identify preoperative factors associated with malignant splenic masses. Methods Pathology records at a single institution were reviewed for all splenectomies. Those performed as a component of a larger resection, such as staging or debulking were excluded. Demographic and clinicopathologic factors were obtained. Univariate and multivariate analyses identified factors associated with an increased risk of malignancy. Results Between 1986 and 2012, 2,743 patients underwent a splenectomy, 148 of which were performed for lesions identified on imaging. The indications were suspicion of malignancy (120, 81%), growth over time (28, 19%), or symptoms (39, 26%). Resected splenic lesions were malignant in 93 patients (63%); the most common pathologies included ovarian cancer (n = 39), melanoma (n = 14), and colorectal cancer (n = 9). On multivariate analysis of clinicopathologic factors, a previous history of cancer was the only independent predictor of malignancy in the splenic lesion (odds ratio 6.3; 95% CI, 2.32-16.97; P = 0.001). Conclusion While the spleen is an uncommon site of metastatic disease, in patients with a history of cancer, splenic masses selected for resection are frequently malignant. J. Surg. Oncol. 2013; 108:521-525. © 2013 Wiley Periodicals, Inc. © 2013 Wiley Periodicals, Inc.
Keywords: splenectomy; metastasis; splenic lesion
Journal Title: Journal of Surgical Oncology
Volume: 108
Issue: 8
ISSN: 0022-4790
Publisher: Wiley Blackwell  
Date Published: 2013-12-01
Start Page: 521
End Page: 525
Language: English
DOI: 10.1002/jso.23433
PROVIDER: scopus
PUBMED: 24105804
DOI/URL:
Notes: --- - "Export Date: 2 December 2013" - "CODEN: JSONA" - "Source: Scopus"
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MSK Authors
  1. Mithat Gonen
    716 Gonen
  2. William R Jarnagin
    596 Jarnagin
  3. Kinh Gian Do
    116 Do
  4. T Peter Kingham
    293 Kingham
  5. Vivian Strong
    148 Strong
  6. Daniel Coit
    422 Coit