Breast cancer in BRCA mutation carriers: Breast-conserving therapy or bilateral mastectomy? Journal Article
| Authors: | Murphy, J. O.; Sacchini, V. S. |
| Article Title: | Breast cancer in BRCA mutation carriers: Breast-conserving therapy or bilateral mastectomy? |
| Abstract: | BRCA mutation carriers who are diagnosed with breast cancer can be overwhelmed with decisions. The choice between breast-conserving therapy, mastectomy or a bilateral mastectomy is often the first to be made by patients. Those who choose breast-conserving therapy are faced with an increased risk of ipsilateral breast tumor recurrence and contralateral breast cancer; however, choosing more extensive surgery increases surgical morbidity without a proven survival advantage. Additional factors that influence surgical decision-making are the use of adjuvant therapy, the role of risk-reducing salpingo-oophorectomy and the biology of the breast cancer. Advances in surgical techniques, breast reconstruction and screening must also be considered when choosing the surgical treatment for breast cancer patients with a BRCA mutation. © 2013 Future Medicine Ltd. |
| Journal Title: | Clinical Practice |
| Volume: | 10 |
| Issue: | 6 |
| ISSN: | 2044-9038 |
| Publisher: | Future Medicine |
| Date Published: | 2013-11-01 |
| Start Page: | 751 |
| End Page: | 764 |
| Language: | English |
| DOI: | 10.2217/cpr.13.72 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 December 2013" - "Source: Scopus" |
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