Prognostic value of the immune microenvironment in lung adenocarcinoma Journal Article
| Authors: | Kadota, K.; Nitadori, J. I.; Adusumilli, P. S. |
| Article Title: | Prognostic value of the immune microenvironment in lung adenocarcinoma |
| Abstract: | We analyzed the immune microenvironment in the neoplastic and stromal components of Stage I lung adenocarcinoma lesions, finding that a high ratio of tumor-infiltrating FOXP3+ regulatory T cells to CD3+ lymphocytes, an elevated expression of the interleukin-7 receptor, as well as a reduced expression of the interleukin-12 receptor β2 all constitute independent factors of poor prognosis. © 2013 Landes Bioscience. |
| Keywords: | signal transduction; protein expression; cancer growth; cancer staging; protein function; transcription factor foxp3; cd8+ t lymphocyte; cell infiltration; regulatory t lymphocyte; lung adenocarcinoma; immune response; cd4+ t lymphocyte; tumor immunity; upregulation; adaptive immunity; cd3+ t lymphocyte; memory t lymphocyte; foxp3; interleukin-7 receptor; tumor microenvironment; interleukin 7 receptor; cancer prognosis; nterleukin-12 receptor; interleukin 12 receptor beta2 |
| Journal Title: | OncoImmunology |
| Volume: | 2 |
| Issue: | 5 |
| ISSN: | 2162-4011 |
| Publisher: | Landes Bioscience |
| Date Published: | 2013-05-01 |
| Start Page: | e24036 |
| Language: | English |
| DOI: | 10.4161/onci.24036 |
| PROVIDER: | scopus |
| PMCID: | PMC3667898 |
| PUBMED: | 23762792 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 December 2013" - "Source: Scopus" |
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496Adusumilli
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