High-risk features in radiation-associated breast angiosarcomas Journal Article


Authors: D'Angelo, S. P.; Antonescu, C. R.; Kuk, D.; Qin, L.; Moraco, N.; Carvajal, R. D.; Chi, P.; Dickson, M. A.; Gounder, M.; Keohan, M. L.; Singer, S.; Schwartz, G. K.; Tap, W. D.
Article Title: High-risk features in radiation-associated breast angiosarcomas
Abstract: Background:Radiation-associated breast angiosarcoma (RT-AS) is an uncommon malignancy with an incidence of less than 1 % of all soft tissue sarcomas. The overall prognosis is quite dismal with high rates of recurrences and poor overall survival. There is an obvious paucity of data regarding clinical outcomes of patients with breast RT-AS.Methods:We identified all patients with RT-AS treated at the Memorial Sloan-Kettering Cancer Center between 1982-2011 and collected their correlative clinical information.Results:We identified 79 women with RT-AS with a median age of 68 (range 36-87). The median interval between radiation and development of RT-AS was 7 years (range 3-19). The median time to local and distant recurrence was 1.29 years (95 % CI 0.72-NA) and 2.48 years (95 % CI 1.29-NA), respectively. The median disease-specific survival was 2.97 years (95 % CI 2.21-NA). Independent predictors of worse disease-specific survival included age ≥68 years (HR 3.11, 95 % CI 1.20-8.08, P=0.020) and deep tumors (HR 3.23, 95 % CI 1.02-10.21, P=0.046.)Conclusion:RT-AS has high local/distant recurrence rates, limited duration on standard chemotherapy and poor disease-specific survival. © 2013 Cancer Research UK.
Keywords: chemotherapy; radiation; surgery; radiation associated breast angiosarcoma
Journal Title: British Journal of Cancer
Volume: 109
Issue: 9
ISSN: 0007-0920
Publisher: Nature Publishing Group  
Date Published: 2013-10-01
Start Page: 2340
End Page: 2346
Language: English
DOI: 10.1038/bjc.2013.590
PROVIDER: scopus
PMCID: PMC3817330
PUBMED: 24104962
DOI/URL:
Notes: --- - "Export Date: 2 December 2013" - "CODEN: BJCAA" - "Source: Scopus"
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MSK Authors
  1. Gary Schwartz
    385 Schwartz
  2. Richard D Carvajal
    148 Carvajal
  3. Cristina R Antonescu
    902 Antonescu
  4. Ping Chi
    175 Chi
  5. Li-Xuan Qin
    193 Qin
  6. Mary Louise Keohan
    126 Keohan
  7. Mrinal M Gounder
    230 Gounder
  8. Sandra Pierina D'Angelo
    254 D'Angelo
  9. Samuel Singer
    337 Singer
  10. Nicole Heather Moraco
    16 Moraco
  11. Mark Andrew Dickson
    172 Dickson
  12. Deborah Kuk
    87 Kuk
  13. William Douglas Tap
    377 Tap