The prognostic value of cardiopulmonary exercise testing in idiopathic pulmonary fibrosis Journal Article


Authors: Fell, C. D.; Liu, L. X.; Motika, C.; Kazerooni, E. A.; Gross, B. H.; Travis, W. D.; Colby, T. V.; Murray, S.; Toews, G. B.; Martinez, F. J.; Flaherty, K. R.
Article Title: The prognostic value of cardiopulmonary exercise testing in idiopathic pulmonary fibrosis
Abstract: Rationale: Idiopathic pulmonary fibrosis (IPF) is characterized by progressive dyspnea, impaired gas exchange, and ultimate mortality. Objectives: To test the hypothesis that maximal oxygen uptake during cardiopulmonary exercise testing at baseline and with short-term longitudinal measures would predict mortality in patients with idiopathic pulmonary fibrosis. Methods: Data from 117 patients with IPF and longitudinal cardiopulmonary exercise tests were examined retrospectively. Survival was calculated from the date of the first cardiopulmonary exercise test. Measurements and Main Results: Patients with baseline maximal oxygen uptake less than 8.3 ml/kg/min had an increased risk of death (n = 8; hazard ratio, 3.24; 95% confidence interval, 1.10-9.56; P = 0.03) after adjusting for age, gender, smoking status, baseline forced vital capacity, and baseline diffusion capacity for carbon monoxide. We were unable to define a unit change in maximal oxygen uptake that predicted survival in our cohort. Conclusions:We conclude that a threshold maximal oxygen uptake of 8.3 ml/kg/min during cardiopulmonary exercise testing at baseline adds prognostic information for patients with IPF.
Keywords: controlled study; human tissue; school child; aged; middle aged; survival rate; retrospective studies; major clinical study; mortality; metabolism; logistic models; proportional hazards models; oxygen; smoking; retrospective study; physiology; kaplan-meiers estimate; proportional hazards model; prediction and forecasting; predictive value of tests; fibrosing alveolitis; kaplan meier method; exercise test; idiopathic pulmonary fibrosis; cardiopulmonary exercise test; lung biopsy; lung function test; oxygen consumption; exercise tolerance; lung fibrosis; statistical model; pulmonary fibrosis
Journal Title: American Journal of Respiratory and Critical Care Medicine
Volume: 179
Issue: 5
ISSN: 1073-449X
Publisher: American Thoracic Society  
Date Published: 2009-03-01
Start Page: 402
End Page: 407
Language: English
DOI: 10.1164/rccm.200802-241OC
PUBMED: 19074597
PROVIDER: scopus
PMCID: PMC2648909
DOI/URL:
Notes: --- - "Cited By (since 1996): 7" - "Export Date: 30 November 2010" - "CODEN: AJCME" - "Source: Scopus"
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  1. William D Travis
    611 Travis