Pretransplantation functional imaging predicts outcome following autologous stem cell transplantation for relapsed and refractory Hodgkin lymphoma Journal Article


Authors: Moskowitz, A. J.; Yahalom, J.; Kewalramani, T.; Maragulia, J. C.; Vanak, J. M.; Zelenetz, A. D.; Moskowitz, C. H.
Article Title: Pretransplantation functional imaging predicts outcome following autologous stem cell transplantation for relapsed and refractory Hodgkin lymphoma
Abstract: To identify prognostic factors for patients transplanted for relapsed or refractory Hodgkin lymphoma we carried out a combined analysis of patients followed prospectively on 3 consecutive protocols at Memorial Sloan-Kettering Cancer Center. One hundred fifty-three patients with chemosensitive disease after ICE (ifosfamide, carboplatin, and etoposide)-based salvage therapy (ST) proceeded to high-dose chemoradiotherapy followed by autologous stem cell transplantation (ASCT). Patients were evaluated with computed tomography and functional imaging (gallium or fluorodeoxyglucose-positron emission tomography) prior to ST and again before ASCT. Functional imaging status before ASCT was the only factor significant for event-free survival (EFS) and overall survival by multivariate analysis and clearly identifies poor risk patients (5-year EFS 31% and 75% for FI-positive and negative patients respectively). Administration of involved-field radiotherapy with ASCT was marginally significant for EFS (P = .055). Studies evaluating novel STs, conditioning regimens, post-ASCT maintenance, or allogeneic stem cell transplantation are warranted for patients who fail to normalize pre-ASCT functional imaging. © 2010 by The American Society of Hematology.
Keywords: adolescent; adult; cancer survival; event free survival; human tissue; treatment outcome; aged; disease-free survival; middle aged; young adult; major clinical study; overall survival; salvage therapy; cancer combination chemotherapy; multimodality cancer therapy; cancer radiotherapy; combined modality therapy; outcome assessment; positron emission tomography; preoperative evaluation; prospective study; carboplatin; computer assisted tomography; neoplasm recurrence, local; etoposide; antineoplastic combined chemotherapy protocols; radiotherapy; relapse; tomography, x-ray computed; cyclophosphamide; autologous stem cell transplantation; hematopoietic stem cell transplantation; prediction; carmustine; ifosfamide; hodgkin disease; risk assessment; positron-emission tomography; transplantation conditioning; immunosuppressive treatment; transplantation, autologous; fluorodeoxyglucose; kaplan-meier estimate; gallium
Journal Title: Blood
Volume: 116
Issue: 23
ISSN: 0006-4971
Publisher: American Society of Hematology  
Date Published: 2010-12-02
Start Page: 4934
End Page: 4937
Language: English
DOI: 10.1182/blood-2010-05-282756
PUBMED: 20733154
PROVIDER: scopus
PMCID: PMC3799204
DOI/URL:
Notes: --- - "Cited By (since 1996): 2" - "Export Date: 20 April 2011" - "CODEN: BLOOA" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Joachim Yahalom
    395 Yahalom
  2. Craig Moskowitz
    372 Moskowitz
  3. Andrew D Zelenetz
    550 Zelenetz
  4. Alison Moskowitz
    141 Moskowitz
  5. Jill M Vanak
    14 Vanak