Squamous cell carcinoma of the oral tongue in the pediatric age group: A matched-pair analysis of survival Journal Article

   

Authors:	Morris, L. G. T.; Patel, S. G.; Shah, J. P.; Ganly, I.
Article Title:	Squamous cell carcinoma of the oral tongue in the pediatric age group: A matched-pair analysis of survival
Abstract:	Objective: To compare outcomes of a pediatric cohort of patients compared with a matched cohort of adult patients, all diagnosed as having squamous cell carcinoma (SCC) of the oral tongue. Outcomes of oral cancer in pediatric patients have not been studied, to our knowledge. Design: Retrospective matched-pair cohort study. Setting: Memorial Sloan-Kettering Cancer Center, New York, New York. Patients: A total of 10 pediatric and 40 adult patients diagnosed as having SCC of the oral tongue. Main Outcome Measures: Overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS). Results: The 5-year OS was equivalent in the 2 groups: 70% in the pediatric group and 64% in the adult group (P=.97). The 5-year DSS was also equivalent: 80% in the pediatric group and 76% in the adult group (P=.90). The 5-year RFS was 70% in the pediatric group and 78% in the adult group (P=.54). Conclusions: When pediatric and adult patients were matched for sex, tobacco use history, TNM status, surgical procedure, and adjuvant radiotherapy, outcomes for OS, DSS, and RFS were equivalent. Pediatric patients with SCC of the oral tongue should be treated similarly to adult patients. ©2010 American Medical Association. All rights reserved.
Keywords:	immunohistochemistry; adolescent; adult; cancer survival; disease-free survival; survival analysis; cancer surgery; retrospective studies; young adult; major clinical study; overall survival; squamous cell carcinoma; carcinoma, squamous cell; cancer radiotherapy; combined modality therapy; radiotherapy, adjuvant; cancer staging; neoplasm staging; cohort studies; neoplasm recurrence, local; cohort analysis; smoking; age factors; retrospective study; groups by age; risk assessment; kaplan-meiers estimate; probability; biopsy, needle; glossectomy; tongue neoplasms; matched-pair analysis; tongue carcinoma; oral surgical procedures
Journal Title:	Archives of Otolaryngology - Head & Neck Surgery
Volume:	136
Issue:	7
ISSN:	0886-4470
Publisher:	American Medical Association
Date Published:	2010-07-01
Start Page:	697
End Page:	701
Language:	English
DOI:	10.1001/archoto.2010.94
PUBMED:	20644066
PROVIDER:	scopus
PMCID:	PMC3005582
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-77954996513&partnerID=40&md5=aa7ce498e41f431f2d812ae1324ad47c
Notes:	--- - "Export Date: 20 April 2011" - "CODEN: AONSE" - "Source: Scopus"

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