Breast cancer arising in a BRCA-mutated background: Therapeutic implications from an animal model and drug development Journal Article
| Authors: | Fasano, J.; Muggia, F. |
| Article Title: | Breast cancer arising in a BRCA-mutated background: Therapeutic implications from an animal model and drug development |
| Abstract: | To date, the presence of a hereditary background has not influenced the selection of drug treatment in breast cancer. However, increasingly, negative hormone receptors and Her2 (often referred to as 'triple negative') or a medullary carcinoma histology has been reported in BRCA mutation carriers. Accordingly, such patients are often considered for adjuvant protocols based on chemotherapy (and not based on endocrine manipulations or trastuzumab). Mouse models introducing a conditional BRCA-null expression in the breast have recently provided powerful support for cisplatin-based treatment and have implications for the design of adjuvant studies in these patients. © The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. |
| Keywords: | cancer chemotherapy; unclassified drug; gene mutation; clinical trial; review; cisplatin; doxorubicin; fluorouracil; drug efficacy; drug potentiation; nonhuman; antineoplastic agents; protein function; animals; heredity; carboplatin; breast cancer; gene expression profiling; epidermal growth factor receptor 2; animal model; antineoplastic activity; drug resistance, neoplasm; dasatinib; drug design; breast neoplasms; brca1 protein; brca2 protein; heterozygote; cetuximab; cancer resistance; docetaxel; chromosome aberration; genes, brca1; genes, brca2; epirubicin; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor; gene silencing; platinum complex; disease models, animal; trastuzumab; hormone receptor; brca; parp1 inhibitor; triple negative; ku 0058684; ku 0058948; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; breast carcinogenesis; drug sensitivity |
| Journal Title: | Annals of Oncology |
| Volume: | 20 |
| Issue: | 4 |
| ISSN: | 0923-7534 |
| Publisher: | Oxford University Press |
| Date Published: | 2009-04-01 |
| Start Page: | 609 |
| End Page: | 614 |
| Language: | English |
| DOI: | 10.1093/annonc/mdn669 |
| PUBMED: | 19150941 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 30 November 2010" - "CODEN: ANONE" - "Source: Scopus" |
