Molecular interactions in the development of brain metastases Journal Article


Authors: Martinez, N.; Boire, A.; De Angelis, L. M.
Article Title: Molecular interactions in the development of brain metastases
Abstract: Brain metastases are a much-feared complication of cancer. The development of brain metastases requires a malignant cell to acquire characteristics that facilitate dissemination away from the primary site, entrance into the nervous system, and establishment in the brain. This review summarizes recent work focused on the molecular derangements leading to brain metastases and outlines areas in need of greater understanding. © 2013 by the authors; licensee MDPI, Basel, Switzerland.
Keywords: unclassified drug; review; nonhuman; paclitaxel; colorectal cancer; gene overexpression; melanoma; breast cancer; epidermal growth factor receptor 2; interleukin 1beta; interleukin 8; lung cancer; prostate cancer; lung adenocarcinoma; tumor necrosis factor alpha; cancer cell; breast carcinoma; blood brain barrier; gefitinib; matrix metalloproteinase; brain metastasis; interleukin 6; molecular interaction; somatomedin c; homeodomain protein; kidney cancer; trastuzumab; cytokine release; cell interaction; tumor seeding; plasminogen activator inhibitor 1; lymphoid enhancer factor 1; dormancy; tumor microenvironment; transforming growth factor beta2; beta1 integrin; heparanase; glycoprotein p inhibitor; n acetylgalactosamine; stromal cell derived factor 1alpha; cns metastasis; metastatic cascade; vascular co-option; hm 30181a; migration inhibition factor; transcription factor hoxb
Journal Title: International Journal of Molecular Sciences
Volume: 14
Issue: 8
ISSN: 1422-0067
Publisher: MDPI  
Date Published: 2013-08-20
Start Page: 17157
End Page: 17167
Language: English
DOI: 10.3390/ijms140817157
PROVIDER: scopus
PMCID: PMC3759957
PUBMED: 23965978
DOI/URL:
Notes: --- - "Export Date: 1 October 2013" - "Source: Scopus"
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MSK Authors
  1. Adrienne Boire
    21 Boire