High expression of SNIP1 correlates with poor prognosis in Non-small cell lung cancer and SNIP1 interferes with the recruitment of HDAC1 to RB in vitro Journal Article
| Authors: | Jeon, H. S.; Choi, Y. Y.; Fukuoka, J.; Fujii, M.; Lyakh, L. A.; Song, S. H.; Travis, W. D.; Park, J. Y.; Jen, J. |
| Article Title: | High expression of SNIP1 correlates with poor prognosis in Non-small cell lung cancer and SNIP1 interferes with the recruitment of HDAC1 to RB in vitro |
| Abstract: | The Rb tumor suppressor gene performs a critical role in controlling cell proliferation and tumorigenesis; it recruits HDAC1 protein into the E2F complexes to repress transcription. In this study, we demonstrate that SNIP1, RB and HDAC1 were significantly expressed in same lung cancer tissues in a tissue microarray (TMA) containing 300 non-small cell lung cancers (NSCLC). High expression level of SNIP1 in tumor patients was significantly correlated with poor prognosis in NSCLC (log-rank P for OS. = 0.01, log-rank P for DFS. = 0.001). Functionally, SNIP1 competes with HDAC1 for binding to RB and reduces HDAC activity in vitro. Knockdown of SNIP1 reduced colony formation ability of lung cancer cells. These findings may indicate the involvement of SNIP1 in progression of lung cancer by regulating the RB/HDAC1 interaction. © 2013 Elsevier Ireland Ltd. |
| Keywords: | adult; human tissue; protein expression; unclassified drug; human cell; cancer growth; gene overexpression; protein p16; gene expression; smad protein; protein protein interaction; lung non small cell cancer; epidermal growth factor receptor 2; lung cancer; cancer cell culture; in vitro study; enzyme activity; correlation analysis; regulatory mechanism; messenger rna; myc protein; gene silencing; cancer tissue; tissue microarray; retinoblastoma protein; histone deacetylase 1; rb; lung parenchyma; e1a associated p300 protein; colony formation; protein c jun; cancer prognosis; hdac1; snip1; smad nuclear interacting protein 1 |
| Journal Title: | Lung Cancer |
| Volume: | 82 |
| Issue: | 1 |
| ISSN: | 0169-5002 |
| Publisher: | Elsevier Ireland Ltd. |
| Date Published: | 2013-10-01 |
| Start Page: | 24 |
| End Page: | 30 |
| Language: | English |
| DOI: | 10.1016/j.lungcan.2013.07.015 |
| PROVIDER: | scopus |
| PUBMED: | 23932364 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 October 2013" - "CODEN: LUCAE" - "Source: Scopus" |
