BRMS1 expression in surgically resected lung adenocarcinoma predicts future metastases and is associated with a poor prognosis Journal Article

   


Authors: Bucciarelli, P. R.; Tan, K. S.; Chudgar, N. P.; Brandt, W.; Montecalvo, J.; Eguchi, T.; Liu, Y.; Aly, R.; Travis, W. D.; Adusumilli, P. S.; Jones, D. R.
Article Title: BRMS1 expression in surgically resected lung adenocarcinoma predicts future metastases and is associated with a poor prognosis
Abstract: Introduction Expression of breast cancer metastasis suppressor 1 gene (BRMS1) is decreased in NSCLC cells and tumors. We hypothesized that intratumoral breast cancer metastasis suppressor 1 (BRMS1) expression is associated with lung adenocarcinoma (LUAD) histologic subtypes and overall survival (OS) and disease-free survival (DFS) in patients undergoing resection for early-stage LUAD. Methods Patients (N = 1030) who underwent complete resection for LUAD with tissue available for histologic evaluation were identified. Tissue microarrays were constructed, and immunostaining was performed and scored for intensity of BRMS1 expression. OS and DFS were estimated (by the Kaplan-Meier method) and compared between groups (by the log-rank test), stratified by stage. Hazard ratios (HRs) for hazard of death and recurrence were estimated using univariable and multivariable Cox proportional hazards models. OS and DFS nomograms were created, and model performance was examined. Results Intratumoral BRMS1 expression was high in 632 patients (61%) and low in 398 (39%). Low BRMS1 expression was associated with higher pathologic T stage (p = 0.001), larger tumor size (p ≤ 0.0001), greater lymphatic (p = 0.032) and vascular (p = 0.001) invasion, LUAD histologic subtype (p = 0.001), and intermediate and high architectural tumor grade (p = 0.003). Low BRMS1 expression was an independent predictor of worse OS (HR = 1.35, 95% confidence interval: 1.10–1.65, p = 0.004) and DFS (HR = 1.27, 95% confidence interval: 1.05–1.54, p = 0.012). OS and DFS nomograms showed excellent predictive performance based on discrimination and calibration. Conclusions Among patients with surgically resected LUAD, OS and DFS were significantly worse in cases with low intratumoral BRMS1 expression. Our findings suggest that BRMS1 is an independent biomarker with prognostic significance in surgically resected LUAD. © 2017 International Association for the Study of Lung Cancer
Keywords: immunohistochemistry; adult; human tissue; aged; major clinical study; overall survival; disease free survival; cancer staging; cancer grading; gene; metastasis; gene expression; tumor volume; lung adenocarcinoma; biomarker; tissue microarray; tumor invasion; histologic subtype; cancer prognosis; human; male; female; priority journal; article; breast cancer metastasis suppressor 1; breast cancer metastasis suppressor 1 gene
Journal Title: Journal of Thoracic Oncology
Volume: 13
Issue: 1
ISSN: 1556-0864
Publisher: Elsevier Inc.  
Date Published: 2018-01-01
Start Page: 73
End Page: 84
Language: English
DOI: 10.1016/j.jtho.2017.10.006
PROVIDER: scopus
PMCID: PMC5738269
PUBMED: 29097253
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85035015130&doi=10.1016%2fj.jtho.2017.10.006&partnerID=40&md5=07506b59e79e67f1101e5bf2176e4974
Notes: Article -- Erratum issued, see DOI 10.1016/j.jtho.2019.03.006 -- Export Date: 6 February 2018 -- Source: Scopus
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MSK Authors
  1. William D Travis
    743 Travis
  2. Prasad S Adusumilli
    496 Adusumilli
  3. David Randolph Jones
    417 Jones
  4. Yuan Liu
    22 Liu
  5. Takashi Eguchi
    71 Eguchi
  6. Neel Pankaj Chudgar
    15 Chudgar
  7. Peter Ryan Bucciarelli
    4 Bucciarelli
  8. Kay See Tan
    241 Tan
  9. Joseph Montecalvo
    43 Montecalvo
  10. Whitney Brandt
    9 Brandt
  11. Rania Gaber Aly
    30 Aly
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