Omega-3 fatty acids for prevention of breast cancer: An update and the state of the science Journal Article
| Authors: | Iyengar, N. M.; Hudis, C. A.; Gucalp, A. |
| Article Title: | Omega-3 fatty acids for prevention of breast cancer: An update and the state of the science |
| Abstract: | The quantity and makeup of dietary fat intake are known to affect human health. A variety of purported health benefits, including cancer prevention, have focused increased attention on use of omega-3 (ω-3) polyunsaturated fatty acid (PUFA) supplements. Preclinical evidence has been encouraging, and recent studies have increased our understanding of mechanisms by means of which ω-3 PUFAs may protect against breast cancer. However, epidemiological studies have yielded mixed results. Recent population studies have attempted to determine factors, for example total fat intake and the ratio of ω-3 to ω-6 PUFA intake, that may affect the action of ω-3 PUFAs. Several clinical trials, some currently ongoing, are investigating strategies to favorably alter endogenous fatty acid profiles in an attempt to develop clinically feasible prevention methods. Identification of well-defined subpopulations who are most likely to benefit from a targeted prevention approach will probably be crucial to this effort. © 2013 Springer Science+Business Media New York. |
| Keywords: | cancer chemotherapy; nonhuman; cancer incidence; prospective study; evidence based medicine; metabolism; cancer prevention; apoptosis; breast cancer; inflammation; risk factors; exercise; obesity; in vivo study; in vitro study; diet supplementation; cancer inhibition; diet; population research; feasibility study; cancer cell; breast carcinoma; tamoxifen; therapy effect; fatty acids; omega 3 fatty acid; fish oil; premenopause; risk reduction; raloxifene; nutrition; prevention; docosahexaenoic acid; icosapentaenoic acid; fat intake; omega 6 fatty acid; polyunsaturated fatty acid; omega-3 polyunsaturated fatty acids; omega-6 polyunsaturated fatty acids; omega 3 acid ethyl ester |
| Journal Title: | Current Breast Cancer Reports |
| Volume: | 5 |
| Issue: | 3 |
| ISSN: | 1943-4588 |
| Publisher: | Springer |
| Date Published: | 2013-09-01 |
| Start Page: | 247 |
| End Page: | 254 |
| Language: | English |
| DOI: | 10.1007/s12609-013-0112-1 |
| PROVIDER: | scopus |
| PMCID: | PMC3780443 |
| PUBMED: | 24073296 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 October 2013" - "Source: Scopus" |
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