Chemical synthesis of highly congested gp120 V1V2 N -glycopeptide antigens for potential HIV-1-directed vaccines Journal Article
| Authors: | Aussedat, B.; Vohra, Y.; Park, P. K.; Fernandez- Tejada, A.; Alam, S. M.; Dennison, S. M.; Jaeger, F. H.; Anasti, K.; Stewart, S.; Blinn, J. H.; Liao, H. X.; Sodroski, J. G.; Haynes, B. F.; Danishefsky, S. J. |
| Article Title: | Chemical synthesis of highly congested gp120 V1V2 N -glycopeptide antigens for potential HIV-1-directed vaccines |
| Abstract: | Critical to the search for an effective HIV-1 vaccine is the development of immunogens capable of inducing broadly neutralizing antibodies (BnAbs). A key first step in this process is to design immunogens that can be recognized by known BnAbs. The monoclonal antibody PG9 is a BnAb that neutralizes diverse strains of HIV-1 by targeting a conserved carbohydrate-protein epitope in the variable 1 and 2 (V1V2) region of the viral envelope. Important for recognition are two closely spaced N-glycans at Asn160 and Asn156. Glycopeptides containing this synthetically challenging bis-N-glycosylated motif were prepared by convergent assembly, and were shown to be antigenic for PG9. Synthetic glycopeptides such as these may be useful for the development of HIV-1 vaccines based on the envelope V1V2 BnAb epitope. © 2013 American Chemical Society. |
| Journal Title: | Journal of the American Chemical Society |
| Volume: | 135 |
| Issue: | 35 |
| ISSN: | 0002-7863 |
| Publisher: | American Chemical Society |
| Date Published: | 2013-01-01 |
| Start Page: | 13113 |
| End Page: | 13120 |
| Language: | English |
| DOI: | 10.1021/ja405990z |
| PROVIDER: | scopus |
| PMCID: | PMC3826081 |
| PUBMED: | 23915436 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 October 2013" - "CODEN: JACSA" - "Source: Scopus" |
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