Functional genomics lead to new therapies in follicular lymphoma Journal Article
| Authors: | Oricchio, E.; Wendel, H. G. |
| Article Title: | Functional genomics lead to new therapies in follicular lymphoma |
| Abstract: | Recent technological advances allow analysis of genomic changes in cancer in unprecedented detail. The next challenge is to prioritize the multitude of genetic aberrations found and identify therapeutic opportunities. We recently completed a study that illustrates the use of unbiased genetic screens and murine cancer models to find therapeutic targets among complex genomic data. We genetically dissected the common deletion of chromosome 6q and identified the ephrin receptor A7 (EPHA7) as a tumor suppressor in lymphoma. Notably, EPHA7 encodes a soluble splice variant that acts as an extrinsic tumor suppressor. Accordingly, we developed an antibody-based strategy to specifically deliver EPHA7 back to tumors that have lost this gene. Recent sequencing studies have implicated EPHA7 in lung cancer and other tumors, suggesting a broader therapeutic potential for antibody-mediated delivery of this tumor suppressor for cancer therapy. Together, our comprehensive approach provides new insights into cancer biology and may directly lead to the development of new cancer therapies. © 2013 New York Academy of Sciences. |
| Keywords: | gene mutation; mutation; nonhuman; antineoplastic agents; lymph nodes; neoplasms; animals; neoplasm proteins; cancer therapy; drug delivery systems; cancer genetics; tumor suppressor gene; antibodies, monoclonal; murinae; genomics; chromosomes, human, pair 6; chromosome deletion; follicular lymphoma; lymphoma, follicular; protein isoforms; functional genomics; chromosome 6q; mouse model; therapies; ephrin receptor a7; genomic data; receptor, epha7 |
| Journal Title: | Annals of the New York Academy of Sciences |
| Volume: | 1293 |
| ISSN: | 0077-8923 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2013-07-01 |
| Start Page: | 18 |
| End Page: | 24 |
| Language: | English |
| DOI: | 10.1111/nyas.12120 |
| PROVIDER: | scopus |
| PUBMED: | 23676193 |
| PMCID: | PMC3987118 |
| DOI/URL: | |
| Notes: | Chapter in "Blavatnik Awards for Young Scientists 2012" (ISBN: 9781573319072) -- "Export Date: 4 September 2013" - "CODEN: ANYAA" - "Source: Scopus" |
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