Mining the cancer genome uncovers therapeutic activity of EphA7 against lymphoma Journal Article
| Authors: | Oricchio, E.; Wendel, H. G. |
| Article Title: | Mining the cancer genome uncovers therapeutic activity of EphA7 against lymphoma |
| Abstract: | The functional annotation of the cancer genome can reveal new opportunities for cancer therapies. The wealth of genomic data on various cancers has not yet been mined for clinically and therapeutically useful information. We use cross-comparisons of genomic data with the results of unbiased genetic screens to prioritize genomic changes for further study. 1,2 In this manner, we have identified a soluble variant of the ephrin receptor A7 (EPHA7 TR) as a tumor suppressor that is lost in lymphoma. We also developed antibody-based delivery to restore this tumor suppressor to the cancer cells in situ. We will discuss our strategy of screening genomic data, specific findings concerning EPHA7 and the potential for future discoveries. © 2012 Landes Bioscience. |
| Keywords: | cancer chemotherapy; protein expression; methylation; review; antineoplastic agents; cancer patient; rituximab; chromosome; phenotype; animals; mice; cell death; cell cycle; protein bcl 2; microrna; gene expression; map kinase signaling system; cell line; rna interference; in vivo study; protein tyrosine kinase; angiogenesis; b lymphocyte; prostate cancer; drug delivery systems; lymphoma, b-cell; antigens, cd20; nonhodgkin lymphoma; recombinant fusion proteins; cancer cell; carcinoma in situ; tumor suppressor proteins; lymphoma; genome; tumor suppressor; ephrin receptor a2; tumor suppressor protein; genetic screening; genetic code; follicular lymphoma; protein isoforms; genetic testing; genome, human; complementary dna; databases, genetic; solubility; genomic in situ hybridization; antibodies, monoclonal, murine-derived; ephrin receptor a7; data mining; genomic data; epha7; ephrin receptor a3; receptor, epha7 |
| Journal Title: | Cell Cycle |
| Volume: | 11 |
| Issue: | 6 |
| ISSN: | 1538-4101 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 2012-03-15 |
| Start Page: | 1076 |
| End Page: | 1080 |
| Language: | English |
| DOI: | 10.4161/cc.11.6.19451 |
| PROVIDER: | scopus |
| PMCID: | PMC3335915 |
| PUBMED: | 22356769 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 11 May 2012" - "Source: Scopus" |
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