Diversity training for signal transduction: Leveraging cell-to-cell variability to dissect cellular signaling, differentiation and death Journal Article

   

Authors:	Cotari, J. W.; Voisinne, G.; Altan-Bonnet, G.
Article Title:	Diversity training for signal transduction: Leveraging cell-to-cell variability to dissect cellular signaling, differentiation and death
Abstract:	Populations of 'identical' cells are rarely truly identical. Even when in the same state of differentiation, isogenic cells may vary in expression of key signaling regulators, activate signal transduction at different thresholds, and consequently respond heterogeneously to a given stimulus. Here, we review how new experimental and analytical techniques are suited to connect these different levels of variability, quantitatively mapping the effects of cell-to-cell variability on cellular decision-making. In particular, we summarize how this helps classify signaling regulators according to the impact of their variability on biological functions. We further discuss how variability can also be leveraged to shed light on the molecular mechanisms regulating cellular signaling, from the individual cell to the population of cells as a whole. © 2013 Elsevier Ltd.
Keywords:	signal transduction; cytology; molecular mechanism; cellular signaling; cells; cell signaling; biological functions; cell-to-cell variability; diversity training; individual cells; isogenic cells
Journal Title:	Current Opinion in Biotechnology
Volume:	24
Issue:	4
ISSN:	0958-1669
Publisher:	Elsevier Inc.
Date Published:	2013-08-01
Start Page:	760
End Page:	766
Language:	English
DOI:	10.1016/j.copbio.2013.05.002
PROVIDER:	scopus
PUBMED:	23747193
PMCID:	PMC3863640
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84880940194&partnerID=40&md5=21dd533965c39a633f815eb35029c5da
Notes:	--- - "Export Date: 4 September 2013" - "CODEN: CUOBE" - "Source: Scopus"

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