Control of microRNA biogenesis and transcription by cell signaling pathways Journal Article
| Authors: | Saj, A.; Lai, E. C. |
| Article Title: | Control of microRNA biogenesis and transcription by cell signaling pathways |
| Abstract: | A limited set of cell-cell signaling pathways presides over the vast majority of animal developmental events. The typical raison d'etre for signal transduction is to control the transcription of protein-coding genes. However, with the recent appreciation of microRNAs, growing attention has been paid towards understanding how signaling pathways intertwine with microRNA-mediated regulation. This review highlights recent studies that uncover unexpected modes of microRNA regulation by cell signaling pathways. Not only can miRNA transcription be positively or negatively regulated by cell signaling, the TGF-β/BMP pathways and Ras/MAPK pathways have now been shown to directly influence microRNA biogenesis to mediate substantial cellular phenotypes. © 2011 Elsevier Ltd. |
| Keywords: | protein expression; review; nonhuman; protein function; phenotype; microrna; smad protein; transforming growth factor beta; genetic transcription; animalia; enzyme regulation; ras protein; biogenesis; intracellular signaling; protein rna binding |
| Journal Title: | Current Opinion in Genetics and Development |
| Volume: | 21 |
| Issue: | 4 |
| ISSN: | 0959-437X |
| Publisher: | Elsevier Inc. |
| Date Published: | 2011-08-01 |
| Start Page: | 504 |
| End Page: | 510 |
| Language: | English |
| DOI: | 10.1016/j.gde.2011.04.010 |
| PROVIDER: | scopus |
| PMCID: | PMC3149747 |
| PUBMED: | 21592778 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 October 2011" - "CODEN: COGDE" - "Source: Scopus" |
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