Biological principles of microRNA-mediated regulation: Shared themes amid diversity Journal Article
| Authors: | Flynt, A. S.; Lai, E. C. |
| Article Title: | Biological principles of microRNA-mediated regulation: Shared themes amid diversity |
| Abstract: | Regulation of gene activity by microRNAs is critical to myriad aspects of eukaryotic development and physiology. Amidst an extensive regulatory web that is predicted to involve thousands of transcripts, emergent themes are now beginning to illustrate how microRNAs have been incorporated into diverse settings. These include potent inhibition of individual key targets, fine-tuning of target activity, the coordinated regulation of target batteries, and the reversibility of some aspects of microRNA-mediated repression. Such themes may reflect some of the inherent advantages of exploiting microRNA control in biological circuits, and provide insight into the consequences of microRNA dysfunction in disease. © 2008 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | unclassified drug; gene mutation; review; nonhuman; phenotype; animals; gene targeting; microrna; gene expression; germ cell; genetic variability; transcription factor; gene expression regulation; eukaryota; species difference; gene control; hematopoiesis; models, genetic; 3' untranslated region; micrornas; gene switching; nerve cell; body patterning; genetic conservation; rna transcription; gene activity; insect genetics; microrna 1; microrna 206; nematode; gene regulatory networks; developmental genetics; plants; hur protein; microrna 122; microrna 150; microrna 223; microrna 279; microrna 8; plant rna; fish genetics; olfactory nerve; plant genetics |
| Journal Title: | Nature Reviews Genetics |
| Volume: | 9 |
| Issue: | 11 |
| ISSN: | 1471-0056 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2008-11-01 |
| Start Page: | 831 |
| End Page: | 842 |
| Language: | English |
| DOI: | 10.1038/nrg2455 |
| PUBMED: | 18852696 |
| PROVIDER: | scopus |
| PMCID: | PMC2729318 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 126" - "Export Date: 17 November 2011" - "CODEN: NRGAA" - "Source: Scopus" |
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