Major vault protein (MVP) gene polymorphisms and drug resistance in mesial temporal lobe epilepsy with hippocampal sclerosis Journal Article


Authors: Balan, S.; lekshmi, S.; Radha, S. K.; Sathyan, S.; Vijai, J.; Banerjee, M.; Radhakrishnan, K.
Article Title: Major vault protein (MVP) gene polymorphisms and drug resistance in mesial temporal lobe epilepsy with hippocampal sclerosis
Abstract: The human major vault protein (MVP) has been implicated in the development of drug resistance in cancer cells. Over expression of MVP has also been reported in brain tissue samples from antiepileptic drug (AED)-resistant human focal epilepsies. To investigate the relationship between single nucleotide polymorphisms (SNPs) involving the MVP gene and AED-resistance, we compared the distribution of three SNPs in the MVP gene, rs4788187, rs3815824 and rs3815823, among 220 patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) (prototype of AED-resistant epilepsy syndrome), 201 patients with juvenile myoclonic epilepsy (JME) (prototype of AED-responsive epilepsy syndrome) and 213 ethnically matched non-epilepsy controls. All the patients and controls were residents of the South Indian state of Kerala for more than three generations. We did not find any significant difference in allele and genotypic frequencies of the studied SNPs between AED-resistant and AED-responsive cohorts, and between AED-resistant and AED-responsive cohorts independently and pooled together when compared with the controls. We conclude that rs4788187, rs3815824, rs3815823 variants of the MVP gene are associated neither with predisposition for epilepsy nor with AED-resistance in the population that we have studied. Our results suggest the need for further research into the link between MVP and AED-resistance. © 2013 Elsevier B.V.
Keywords: adolescent; adult; controlled study; young adult; major clinical study; single nucleotide polymorphism; polymorphism, single nucleotide; allele; genotype; alleles; gene frequency; linkage disequilibrium; drug resistance; anticonvulsive agent; polymorphism, genetic; electroencephalogram; anticonvulsants; sclerosis; hippocampus; lung resistance protein; gene linkage disequilibrium; eeg; snp; genetic variants; major vault protein; epilepsy, temporal lobe; mvp; vault ribonucleoprotein particles; juvenile myoclonic epilepsy; temporal lobe epilepsy; hippocampal sclerosis; mesial temporal lobe epilepsy; myoclonus epilepsy; abc; aed; anterior temporal lobectomy; anti-epileptic drug; atl; atp-binding cassette; jme; ld; mesial temporal lobe epilepsy with hippocampal sclerosis; mtle-hs
Journal Title: Gene
Volume: 526
Issue: 2
ISSN: 0378-1119
Publisher: Elsevier Science, Inc.  
Date Published: 2013-09-10
Start Page: 449
End Page: 453
Language: English
DOI: 10.1016/j.gene.2013.05.067
PROVIDER: scopus
PUBMED: 23751308
DOI/URL:
Notes: --- - "Export Date: 4 September 2013" - "CODEN: GENED" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Vijai Joseph
    117 Joseph