Administration of ATRA to newly diagnosed patients with acute promyelocytic leukemia is delayed contributing to early hemorrhagic death Journal Article
| Authors: | Altman, J. K.; Rademaker, A.; Cull, E.; Weitner, B. B.; Ofran, Y.; Rosenblat, T. L.; Haidau, A.; Park, J. H.; Ram, S. L.; Orsini, J. M.; Sandhu, S.; Catchatourian, R.; Trifilio, S. M.; Adel, N. G.; Frankfurt, O.; Stein, E. M.; Mallios, G.; Deblasio, T.; Jurcic, J. G.; Nimer, S.; Peterson, L. C.; Kwaan, H. C.; Rowe, J. M.; Douer, D.; Tallman, M. S. |
| Article Title: | Administration of ATRA to newly diagnosed patients with acute promyelocytic leukemia is delayed contributing to early hemorrhagic death |
| Abstract: | We hypothesized that the high early death rate (EDR) due to bleeding in acute promyelocytic leukemia (APL) is in part attributable to delays in all- trans retinoic acid (ATRA). We conducted a retrospective analysis of the timing of ATRA administration. 204 consecutive patients with newly diagnosed APL between 1992 and 2009 were identified. The EDR was 11%. 44% of early deaths occurred in the first week. Hemorrhage accounted for 61% of early deaths. ATRA was ordered the day APL was suspected in 31% of patients. Delays in ATRA administration led to increases in the percentage of early deaths from hemorrhage. © 2013 Elsevier Ltd. |
| Keywords: | acute promyelocytic leukemia; hemorrhage; atra; early death rate |
| Journal Title: | Leukemia Research |
| Volume: | 37 |
| Issue: | 9 |
| ISSN: | 0145-2126 |
| Publisher: | Elsevier Ltd |
| Date Published: | 2013-09-01 |
| Start Page: | 1004 |
| End Page: | 1009 |
| Language: | English |
| DOI: | 10.1016/j.leukres.2013.05.007 |
| PROVIDER: | scopus |
| PUBMED: | 23768930 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 September 2013" - "CODEN: LERED" - "Source: Scopus" |
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