Provocative pearls in diagnosing and treating acute promyelocytic leukemia Journal Article
| Authors: | Stein, E. M.; Tallman, M. S. |
| Article Title: | Provocative pearls in diagnosing and treating acute promyelocytic leukemia |
| Abstract: | The introduction of all-trans retinoic acid (ATRA) into routine clinical practice changed the outcome of acute promyelocytic leukemia (APL) from the most fatal to the most curable subtype of acute myeloid leukemia (AML). Patients who do not survive generally succumb within the first 30 days after presentation or diagnosis, often from intracranial or pulmonary hemorrhage caused by the characteristic coagulopathy associated with this disease. For the majority of patients who avoid hemorrhagic complications, the goals of decreasing the side effects of diagnosis and treatment-including pain, inpatient hospital days, and late sequelae of cytotoxic chemotherapy-have emerged as paramount. Here, we discuss novel and provocative observations regarding diagnostic and treatment strategies for APL that are likely to emerge as standards of care in the next 5 years, and that may improve the rate of early hemorrhagic death and decrease diagnosis- and treatment-related morbidity. |
| Keywords: | mortality; review; antineoplastic agents; clinical trials as topic; antineoplastic agent; bone marrow; dexamethasone; practice guideline; pathology; arsenic trioxide; arsenicals; leukemia, promyelocytic, acute; oxides; needle biopsy; biopsy, fine-needle; practice guidelines as topic; promyelocytic leukemia; remission; remission induction; antineoplastic agents, hormonal; retinoic acid; antineoplastic hormone agonists and antagonists; respiratory insufficiency; respiratory failure; clinical trial (topic); lung edema; tretinoin; granulocyte precursor; organoarsenic derivative; oxide; pulmonary edema; granulocyte precursor cells |
| Journal Title: | Oncology (Norwalk) |
| Volume: | 26 |
| Issue: | 7 |
| ISSN: | 0890-9091 |
| Publisher: | C M P Medica LLC * The Oncology Group |
| Date Published: | 2012-07-01 |
| Start Page: | 636 |
| End Page: | 641 |
| Language: | English |
| PUBMED: | 22888564 |
| PROVIDER: | scopus |
| PMCID: | PMC4075426 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 February 2013" - "Source: Scopus" |
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