Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer Journal Article
| Authors: | Amundadottir, L.; Kraft, P.; Stolzenberg-Solomon, R. Z.; Fuchs, C. S.; Petersen, G. M.; Arslan, A. A.; Bueno-de-Mesquita, H. B.; Gross, M.; Helzlsouer, K.; Jacobs, E. J.; LaCroix, A.; Zheng, W.; Albanes, D.; Bamlet, W.; Berg, C. D.; Berrino, F.; Bingham, S.; Buring, J. E.; Bracci, P. M.; Canzian, F.; Clavel-Chapelon, F.; Clipp, S.; Cotterchio, M.; De Andrade, M.; Duell, E. J.; Fox, J. W. Jr; Gallinger, S.; Gaziano, J. M.; Giovannucci, E. L.; Goggins, M.; González, C. A.; Hallmans, G.; Hankinson, S. E.; Hassan, M.; Holly, E. A.; Hunter, D. J.; Hutchinson, A.; Jackson, R.; Jacobs, K. B.; Jenab, M.; Kaaks, R.; Klein, A. P.; Kooperberg, C.; Kurtz, R. C.; Li, D.; Lynch, S. M.; Mandelson, M.; McWilliams, R. R.; Mendelsohn, J. B.; Michaud, D. S.; Olson, S. H.; Overvad, K.; Patel, A. V.; Peeters, P. H. M.; Rajkovic, A.; Riboli, E.; Risch, H. A.; Shu, X. O.; Thomas, G.; Tobias, G. S.; Trichopoulos, D.; Van Den Eeden, S. K.; Virtamo, J.; Wactawski-Wende, J.; Wolpin, B. M.; Yu, H.; Yu, K.; Zeleniuch-Jacquotte, A.; Chanock, S. J.; Hartge, P.; Hoover, R. N. |
| Article Title: | Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer |
| Abstract: | We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 × 10<sup>-8</sup>; multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B. © 2009 Nature America, Inc. All rights reserved. |
| Keywords: | cancer survival; controlled study; survival rate; major clinical study; single nucleotide polymorphism; case control study; case-control studies; polymorphism, single nucleotide; cancer risk; united states; pancreas cancer; pancreatic neoplasms; prospective studies; cancer susceptibility; genetic predisposition to disease; cohort studies; logistic models; blood group a; blood group abo system; blood group b; blood group o; chromosome 9p; cohort analysis; gene locus; genetic association; genetic variability; genotype; intron; abo blood-group system; alleles; chromosomes, human, pair 9; gene frequency; genetic variation; genome-wide association study; haplotypes; introns; linkage disequilibrium; odds ratio; risk factors |
| Journal Title: | Nature Genetics |
| Volume: | 41 |
| Issue: | 9 |
| ISSN: | 1061-4036 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2009-09-01 |
| Start Page: | 986 |
| End Page: | 990 |
| Language: | English |
| DOI: | 10.1038/ng.429 |
| PUBMED: | 19648918 |
| PROVIDER: | scopus |
| PMCID: | PMC2839871 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 22" - "Export Date: 30 November 2010" - "CODEN: NGENE" - "Source: Scopus" |
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