Endometrial sampling diagnosis of FIGO grade 1 endometrial adenocarcinoma with a background of complex atypical hyperplasia and final hysterectomy pathology Journal Article

  

Authors:	Leitao, M. M. Jr; Kehoe, S.; Barakat, R. R.; Alektiar, K.; Rabbitt, C.; Chi, D. S.; Soslow, R. A.; Abu-Rustum, N. R.
Article Title:	Endometrial sampling diagnosis of FIGO grade 1 endometrial adenocarcinoma with a background of complex atypical hyperplasia and final hysterectomy pathology
Abstract:	Objective: The purpose of this study was to determine posthysterectomy pathologic findings in patients with a preoperative endometrial sampling diagnosis of International Federation of Gynecology and Obstetrics (FIGO) grade 1 endometrial adenocarcinoma with a background of complex atypical hyperplasia (CAH). Study Design: We reviewed 1423 consecutive cases of endometrial cancer to identify cases with a preoperative endometrial biopsy that demonstrated FIGO grade 1 endometrial adenocarcinoma. Final uterine pathologic findings were grouped into low- and high-risk based on FIGO and Gynecologic Oncology Group criteria. Results: We identified 123 cases with a background of CAH and 367 cases without a background of CAH. FIGO grade in the hysterectomy specimen was more than FIGO grade 1 in 11 of 123 cases (8.9%) with a background of CAH, compared with 60 of 359 cases (16.7%) without a background of CAH (P = .04). Conclusion: An endometrial sampling diagnosis of FIGO grade 1 endometrial adenocarcinoma with a background of CAH is more likely to correlate with final posthysterectomy grade than a diagnosis not arising with a background of CAH. © 2010 Mosby, Inc. All rights reserved.
Keywords:	adult; controlled study; human tissue; aged; aged, 80 and over; middle aged; major clinical study; histopathology; postoperative period; cancer diagnosis; endometrium carcinoma; hysterectomy; endometrial neoplasms; cancer grading; adenocarcinoma; biopsy; preoperative period; hyperplasia; medical society; vaginal hysterectomy; endometrium; endometrium biopsy; complex atypical hyperplasia (cah); endometrial adenocarcinoma; endometrial sampling; posthysterectomy pathologic finding; endometrium hyperplasia
Journal Title:	American Journal of Obstetrics and Gynecology
Volume:	202
Issue:	3
ISSN:	0002-9378
Publisher:	Elsevier Inc.
Date Published:	2010-03-01
Start Page:	278.e1
End Page:	278.e6
Language:	English
DOI:	10.1016/j.ajog.2009.10.882
PUBMED:	20022581
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-77649189031&partnerID=40&md5=27545fc5ec99b21a002dc96c3213934e
Notes:	--- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: AJOGA" - "Source: Scopus"

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