Electrical impedance characterization of normal and cancerous human hepatic tissue Journal Article
| Authors: | Laufer, S.; Ivorra, A.; Reuter, V. E.; Rubinsky, B.; Solomon, S. B. |
| Article Title: | Electrical impedance characterization of normal and cancerous human hepatic tissue |
| Abstract: | The four-electrode method was used to measure the ex vivo complex electrical impedance of tissues from 14 hepatic tumors and the surrounding normal liver from six patients. Measurements were done in the frequency range 1-400 kHz. It was found that the conductivity of the tumor tissue was much higher than that of the normal liver tissue in this frequency range (from 0.14 0.06 S m-1 versus 0.03 0.01 S m-1 at 1 kHz to 0.25 0.06 S m-1 versus 0.15 0.03 S m-1 at 400 kHz). The Cole-Cole models were estimated from the experimental data and the four parameters (ρ0, ρ∞, α, fc) were obtained using a least-squares fit algorithm. The Cole-Cole parameters for the cancerous and normal liver are 9 4 Ω m-1, 2.2 0.7 Ω m-1, 0.5 0.2, 140 103 kHz and 50 28 Ω m-1, 3.2 0.6 Ω m-1, 0.64 0.04, 10 7 kHz, respectively. These data can contribute to developing bioelectric applications for tissue diagnostics and in tissue treatment planning with electrical fields such as radiofrequency tissue ablation, electrochemotherapy and gene therapy with reversible electroporation, nanoscale pulsing and irreversible electroporation. © 2010 Institute of Physics and Engineering in Medicine. |
| Keywords: | adult; aged; aged, 80 and over; middle aged; liver cirrhosis; liver neoplasms; pathology; liver; liver tumor; liver cancer; electric impedance; electrode; bioimpedance; impedance; electrodes |
| Journal Title: | Physiological Measurement |
| Volume: | 31 |
| Issue: | 7 |
| ISSN: | 0967-3334 |
| Publisher: | Institute of Physics and Engineering in Medicine |
| Date Published: | 2010-07-01 |
| Start Page: | 995 |
| End Page: | 1009 |
| Language: | English |
| DOI: | 10.1088/0967-3334/31/7/009 |
| PUBMED: | 20577035 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 20 April 2011" - "CODEN: PMEAE" - "Source: Scopus" |
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