Solid-phase peptide synthesis and solid-phase fragment coupling mediated by isonitriles Journal Article
| Authors: | Wang, T.; Danishefsky, S. J. |
| Article Title: | Solid-phase peptide synthesis and solid-phase fragment coupling mediated by isonitriles |
| Abstract: | The synthesis of polypeptides on solid phase via mediation by isonitriles is described. The acyl donor is a thioacid, which presumably reacts with the isonitrile to generate a thio-formimidate carboxylate mixed anhydride intermediate. Applications of this chemistry to reiterative solid-phase peptide synthesis as well as solid-phase fragment coupling are described. |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 110 |
| Issue: | 29 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 2013-07-16 |
| Start Page: | 11708 |
| End Page: | 11713 |
| Language: | English |
| DOI: | 10.1073/pnas.1310431110 |
| PROVIDER: | scopus |
| PMCID: | PMC3718127 |
| PUBMED: | 23821753 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 August 2013" - "CODEN: PNASA" - "Source: Scopus" |
