Amidoglycosylation of polymer-bound glycals: A complete solid-phase synthesis of the oligosaccharide domain of the Lewis(b) blood group determinant Journal Article
| Authors: | Zheng, C.; Seeberger, P. H.; Danishefsky, S. J. |
| Article Title: | Amidoglycosylation of polymer-bound glycals: A complete solid-phase synthesis of the oligosaccharide domain of the Lewis(b) blood group determinant |
| Abstract: | A new general method for the preparation of N-acetylglucosamine glycosidic linkages has been developed for solid-phase synthesis. The complete pentasaccharide domain of the Lewisb blood group antigen, which is a mediator in the formation of ulcers and gastric cancer, has now been synthesized on solid support (see 1: the shaded circle is the polystyrene support: TIPS = triisopropylsilyl). |
| Keywords: | glycosylations; solid-phase synthesis; oligosaccharides; glycals |
| Journal Title: | Angewandte Chemie - International Edition |
| Volume: | 37 |
| Issue: | 6 |
| ISSN: | 1433-7851 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1998-01-01 |
| Start Page: | 786 |
| End Page: | 789 |
| Language: | English |
| DOI: | 10.1002/(sici)1521-3773(19980403)37:6<786::aid-anie786>3.0.co;2-f |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
