Pattern recognition analysis in complex molecule synthesis and the preparation of iso-Diels -Alder motifs Journal Article

   


Authors: Peng, F.; Grote, R. E.; Wilson, R. M.; Danishefsky, S. J.
Article Title: Pattern recognition analysis in complex molecule synthesis and the preparation of iso-Diels -Alder motifs
Abstract: The identification of synthesizable substructural domains within more complex structural targets is of significant value in designing a workable plan of synthesis. We term this process "pattern recognition analysis" (PRA). In this paper we continued to build on the theme of PRA as a potential resource in retrosynthetic blueprints to reach highly challenging targets. The paper operates at two levels. First, there is provided a clear sense of definitions of categories by which patterns are related to hypothetical reaction types. Although the required reaction type may for the moment not exist, we believe that this method of analysis is likely to promote innovation that identifies unmet needs and opportunities to advance the cause of complex target synthesis. In addition, we describe reductions to practice in expanding the menu of achievable patterns. It is likely that the future value of PRA will be associated with its utility in leading the way to new and exploitable chemical innovation.
Keywords: chemical analysis; chemical structure; molecular structure; synthesis; ring closing metathesis; stereoisomerism; reduction; pattern recognition; chemistry techniques, synthetic; pattern analysis; pattern recognition analysis; cycloaddition reaction
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Volume: 110
Issue: 27
ISSN: 0027-8424
Publisher: National Academy of Sciences  
Date Published: 2013-07-02
Start Page: 10904
End Page: 10909
Language: English
DOI: 10.1073/pnas.1309795110
PROVIDER: scopus
PMCID: PMC3703981
PUBMED: 23784777
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84879731085&partnerID=40&md5=a501d8c602352cf844e2884a925218e0
Notes: --- - "Export Date: 1 August 2013" - "CODEN: PNASA" - "Source: Scopus"
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MSK Authors
  1. Samuel J Danishefsky
    539 Danishefsky
  2. Rebecca Wilson
    17 Wilson
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