Model selection in competing risks regression Journal Article

Authors: Kuk, D.; Varadhan, R.
Article Title: Model selection in competing risks regression
Abstract: In the analysis of time-to-event data, the problem of competing risks occurs when an individual may experience one, and only one, of m different types of events. The presence of competing risks complicates the analysis of time-to-event data, and standard survival analysis techniques such as Kaplan-Meier estimation, log-rank test and Cox modeling are not always appropriate and should be applied with caution. Fine and Gray developed a method for regression analysis that models the hazard that corresponds to the cumulative incidence function. This model is becoming widely used by clinical researchers and is now available in all the major software environments. Although model selection methods for Cox proportional hazards models have been developed, few methods exist for competing risks data. We have developed stepwise regression procedures, both forward and backward, based on AIC, BIC, and BICcr (a newly proposed criteria that is a modified BIC for competing risks data subject to right censoring) as selection criteria for the Fine and Gray model. We evaluated the performance of these model selection procedures in a large simulation study and found them to perform well. We also applied our procedures to assess the importance of bone mineral density in predicting the absolute risk of hip fracture in the Women's Health Initiative-Observational Study, where mortality was the competing risk. We have implemented our method as a freely available R package called crrstep. © 2013 John Wiley & Sons, Ltd.
Keywords: cumulative incidence; competing risks; aic; bic; fine and gray model; stepwise regression
Journal Title: Statistics in Medicine
Volume: 32
Issue: 18
ISSN: 0277-6715
Publisher: John Wiley & Sons  
Date Published: 2013-08-15
Start Page: 3077
End Page: 3088
Language: English
DOI: 10.1002/sim.5762
PROVIDER: scopus
PUBMED: 23436643
Notes: --- - "Export Date: 1 August 2013" - "CODEN: SMEDD" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Deborah Kuk
    86 Kuk