Time-to-event modelling of effect of codrituzumab on overall survival in patients with hepatocellular carcinoma Journal Article


Authors: Nakamura, M.; Xu, C.; Diack, C.; Ohishi, N.; Lee, R. M.; Iida, S.; Kawanishi, T.; Ohtomo, T.; Abou-Alfa, G. K.; Chen, Y. C.
Article Title: Time-to-event modelling of effect of codrituzumab on overall survival in patients with hepatocellular carcinoma
Abstract: Aims: Codrituzumab (GC33) is a recombinant, humanized mAb that binds to glypican-3 (GPC3), an oncofetal protein highly expressed in hepatocellular carcinoma (HCC). This investigation aimed to identify clinically relevant factors that may affect the overall survival (OS) in HCC patients treated with codrituzumab and to quantitatively annotate their effects. Methods: Codrituzumab exposure was estimated by a population pharmacokinetics model with a nonlinear elimination pathway. Analysis of OS was performed using a time-to-event model in 181 patients with advanced HCC. The model was tested with the addition of various covariates, including levels of immune biomarkers, such as CD16 (measured in terms of molecules of equivalent soluble fluorophore; CD16MESF) and CD4, codrituzumab exposure and potential prognostic biomarkers of HCC such as baseline tumour size and soluble GPC3. Results: The time-to-event model estimated a prolonged OS (>3 months) in patients with codrituzumab exposure of ≥230 μg ml−1 and high CD16MESF level (>5.26 × 105 MESF at least). The Weibull model was selected as the base hazard model. The baseline tumour size was included in the hazard model as a parameter independent of the drug effect. A logistic model was applied to explain the effects of drug exposure and CD16MESF level. Conclusions: The final model indicates that adequate drug exposure plus a favourable immune environment are associated with prolonged OS. This quantitative model should be further validated with emerging data so as to guide study design in future clinical trials. © 2018 The British Pharmacological Society
Keywords: overall survival; hepatocellular carcinoma; pharmacokinetics; gpc3; gc33/codrituzumab; time-to-event model
Journal Title: British Journal of Clinical Pharmacology
Volume: 84
Issue: 5
ISSN: 0306-5251
Publisher: Wiley Blackwell  
Date Published: 2018-05-01
Start Page: 944
End Page: 951
Language: English
DOI: 10.1111/bcp.13530
PROVIDER: scopus
PMCID: PMC5903238
PUBMED: 29381229
DOI/URL:
Notes: Article -- Export Date: 1 May 2018 -- Source: Scopus
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  1. Ghassan Abou-Alfa
    381 Abou-Alfa