Late toxicity and patient self-assessment of breast appearance/satisfaction on RTOG 0319: A phase 2 trial of 3-dimensional conformal radiation therapy-accelerated partial breast irradiation following lumpectomy for stages i and II breast cancer Journal Article
| Authors: | Chafe, S.; Moughan, J.; McCormick, B.; Wong, J.; Pass, H.; Rabinovitch, R.; Arthur, D. W.; Petersen, I.; White, J.; Vicini, F. A. |
| Article Title: | Late toxicity and patient self-assessment of breast appearance/satisfaction on RTOG 0319: A phase 2 trial of 3-dimensional conformal radiation therapy-accelerated partial breast irradiation following lumpectomy for stages i and II breast cancer |
| Abstract: | Purpose: Late toxicities and cosmetic analyses of patients treated with accelerated partial breast irradiation (APBI) on RTOG 0319 are presented. Methods and Materials: Patients with stages I to II breast cancer ≤3 cm, negative margins, and ≤3 positive nodes were eligible. Patients received three-dimensional conformal external beam radiation therapy (3D-CRT; 38.5 Gy in 10 fractions twice daily over 5 days). Toxicity and cosmesis were assessed by the patient (P), the radiation oncologist (RO), and the surgical oncologist (SO) at 3, 6, and 12 months from the completion of treatment and then annually. National Cancer Institute Common Terminology Criteria for Adverse Events, version 3.0, was used to grade toxicity. Results: Fifty-two patients were evaluable. Median follow-up was 5.3 years (range, 1.7-6.4 years). Eighty-two percent of patients rated their cosmesis as good/excellent at 1 year, with rates of 64% at 3 years. At 3 years, 31 patients were satisfied with the treatment, 5 were not satisfied but would choose 3D-CRT again, and none would choose standard radiation therapy. The worst adverse event (AE) per patient reported as definitely, probably, or possibly related to radiation therapy was 36.5% grade 1, 50% grade 2, and 5.8% grade 3 events. Grade 3 AEs were all skin or musculoskeletal-related. Treatment-related factors were evaluated to potentially establish an association with observed toxicity. Surgical bed volume, target volume, the number of beams used, and the use of bolus were not associated with late cosmesis. Conclusions: Most patients enrolled in RTOG 0319 were satisfied with their treatment, and all would choose to have the 3D-CRT APBI again. © 2013 Elsevier Inc. |
| Keywords: | treatment outcome; patient satisfaction; cancer surgery; major clinical study; fatigue; three dimensional; treatment planning; cancer staging; follow up; neoplasm staging; breast cancer; breast; esophagitis; leukopenia; nausea; stomatitis; myalgia; radiotherapy; patient monitoring; breast neoplasms; radiation response; arthralgia; pruritus; lymphedema; radiation dose fractionation; three dimensional imaging; thrombosis; cancer size; partial mastectomy; irradiation; radiation injuries; muscle weakness; peripheral edema; hyperpigmentation; surgery; telangiectasia; hot flush; radiotherapy, conformal; external beam radiotherapy; esthetics; toxicity; dose fractionation; dry skin; seroma; organ size; alopecia; lung fibrosis; diseases; self evaluation; radiation dermatitis; mastectomy, segmental; radiation oncologists; carcinoma, ductal, breast; skin atrophy; hypopigmentation; accelerated partial breast irradiation; external beam radiation therapy; mastalgia; myositis; erythema multiforme; skin fibrosis; partial breast irradiation; common terminology criteria; national cancer institute; genital edema; methods and materials; erythroderma; patient self-assessment; conformal mapping; breast hypoplasia; breast malformation; nipple malformation; diagnostic self evaluation |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 86 |
| Issue: | 5 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2013-08-01 |
| Start Page: | 854 |
| End Page: | 859 |
| Language: | English |
| DOI: | 10.1016/j.ijrobp.2013.04.005 |
| PROVIDER: | scopus |
| PUBMED: | 23726000 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 August 2013" - "CODEN: IOBPD" - "Source: Scopus" |
