Does pre-operative chemoradiation for initially unresectable or borderline resectable pancreatic adenocarcinoma increase post-operative morbidity? A case-matched analysis Journal Article

   

Authors:	Araujo, R. L. C.; Gaujoux, S.; Huguet, F.; Gonen, M.; D'Angelica, M. I.; DeMatteo, R. P.; Fong, Y.; Kingham, T. P.; Jarnagin, W. R.; Goodman, K. A.; Allen, P. J.
Article Title:	Does pre-operative chemoradiation for initially unresectable or borderline resectable pancreatic adenocarcinoma increase post-operative morbidity? A case-matched analysis
Abstract:	Background Neoadjuvant chemoradiation therapy for locally unresectable and borderline resectable pancreatic cancer may allow some patients to a undergo a resection, but whether or not this increases post-operative morbidity remains unclear. Methods The post-operative morbidity of 29 patients with initially locally unresectable/borderline pancreatic cancer who underwent a resection were compared with 29 patients with initially resectable tumours matched for age, gender, the presence of comorbidities (yes/no), American Society of Anesthesiology (ASA) score, tumour location (head/body-tail), procedure (pancreaticoduodenectomy/distal pancreatectomy) and vascular resection (yes /no). Wilcoxon's signed ranks test was used for continuous variables and McNemar's chi-square test for categorical variables. Results Compared with patients with initially resectable tumours, patients who underwent a resection after pre-operative chemoradiation therapy had similar rates of overall post-operative complications (55% versus 41%, P = 0.42), major complications (21% versus 21%, P = 1), pancreatic leaks and fistulae (7% versus 10%, P = 1) and mortality (0% versus 1.7%, P = 1). Conclusion Although some previous studies have suggested differences in post-operative morbidity after chemoradiation, our case-matched analysis did not find statistical differences in surgical morbidity and mortality associated with pre-operative chemoradiation therapy. © 2013 International Hepato-Pancreato-Biliary Association.
Journal Title:	HPB
Volume:	15
Issue:	8
ISSN:	1365-182X
Publisher:	Elsevier Science, Inc.
Date Published:	2013-08-01
Start Page:	574
End Page:	580
Language:	English
DOI:	10.1111/hpb.12033
PROVIDER:	scopus
PUBMED:	23458208
PMCID:	PMC3731577
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84880152132&partnerID=40&md5=2b2dcb04815b15cd7e35f665e1260d71
Notes:	"Export Date: 1 August 2013" - "CODEN: HPBIF" - "Source: Scopus"

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