Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia Journal Article

   

Authors:	Ramos, P.; Casu, C.; Gardenghi, S.; Breda, L.; Crielaard, B. J.; Guy, E.; Marongiu, M. F.; Gupta, R.; Levine, R. L.; Abdel-Wahab, O.; Ebert, B. L.; Van Rooijen, N.; Ghaffari, S.; Grady, R. W.; Giardina, P. J.; Rivella, S.
Article Title:	Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia
Abstract:	Regulation of erythropoiesis is achieved by the integration of distinct signals. Among them, macrophages are emerging as erythropoietin-complementary regulators of erythroid development, particularly under stress conditions. We investigated the contribution of macrophages to physiological and pathological conditions of enhanced erythropoiesis. We used mouse models of induced anemia, polycythemia vera and β-thalassemia in which macrophages were chemically depleted. Our data indicate that macrophages contribute decisively to recovery from induced anemia, as well as the pathological progression of polycythemia vera and β-thalassemia, by modulating erythroid proliferation and differentiation. We validated these observations in primary human cultures, showing a direct impact of macrophages on the proliferation and enucleation of erythroblasts from healthy individuals and patients with polycythemia vera or β-thalassemia. The contribution of macrophages to stress and pathological erythropoiesis, which we have termed stress erythropoiesis macrophage-supporting activity, may have therapeutic implications. © 2013 Nature America, Inc. All rights reserved.
Keywords:	human cell; nonhuman; pathophysiology; cell proliferation; animal cell; mouse; animal; animals; mice; anemia; erythroblast; erythropoiesis; stress, physiological; animal experiment; animal model; hemoglobin; drug effect; mice, inbred c57bl; physiology; c57bl mouse; disease model; beta thalassemia; beta-thalassemia; enucleation; disease models, animal; macrophage; macrophages; hemoglobins; polycythemia vera; hematocrit; erythrocyte count; clodronic acid; reticulocyte; physiological stress; reticulocytes
Journal Title:	Nature Medicine
Volume:	19
Issue:	4
ISSN:	1078-8956
Publisher:	Nature Publishing Group
Date Published:	2013-04-01
Start Page:	437
End Page:	445
Language:	English
DOI:	10.1038/nm.3126
PUBMED:	23502961
PROVIDER:	scopus
PMCID:	PMC3618568
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84878439561&partnerID=40&md5=a99b43f9b539305fa6327723a5aa087b
Notes:	--- - Cited By (since 1996):2 - "Export Date: 19 July 2013" - "CODEN: NAMEF" - "Source: Scopus"

https://synapse.mskcc.org/synapse/works/has_related_data_chk/44136