Low expression of SHP-2 is associated with less favorable prostate cancer outcomes Journal Article
| Authors: | Tassidis, H.; Brokken, L. J. S.; Jirstrom, K.; Bjartell, A.; Ulmert, D.; Härkönen, P.; Wingren, A. G. |
| Article Title: | Low expression of SHP-2 is associated with less favorable prostate cancer outcomes |
| Abstract: | Abstact: Src homology 2 domain-containing tyrosine phosphatase-2 (SHP-2) is an important regulator of cell signaling because of its ability to dephosphorylate receptors of growth factors as well as the cytokines and tyrosine-phosphorylated proteins associated with these receptors. In the current study, we used four different prostate cancer cell lines: PC3, DU145, LNCaP and LNCaP-IL6+. Tumor specimens from 122 patients with prostate cancer were analyzed using a tissue microarray. Our data demonstrate that all four prostate cancer cell lines express the SHP-2 protein. Additionally, low staining intensity and SHP-2 expression in the cytoplasm of cancer cells in prostate tumor specimens was inversely correlated with prostate volume (p = 0.041 and p = 0.042, respectively) whereas nuclear staining was positively correlated with extracapsular extension (p = 0.039). In our post-prostatectomy specimens, we found that patients with low SHP-2 expression had less favorable outcomes with respect to biochemical recurrence and clinical progression (p = 0.005 and p = 0.018, respectively). The loss of cytoplasmic SHP-2 expression is associated with increased growth and prostatic cancer progression. © 2012 International Society of Oncology and BioMarkers (ISOBM). |
| Keywords: | signal transduction; aged; middle aged; survival rate; disease course; mortality; cancer staging; follow up; follow-up studies; neoplasm staging; metabolism; pathology; tumor cell culture; tumor cells, cultured; phosphorylation; prostate cancer; prostatic neoplasms; enzyme immunoassay; immunoenzyme techniques; prostatectomy; disease progression; prostate tumor; cytoplasm; tissue array analysis; tissue microarray; stroma cell; stromal cells; protein tyrosine phosphatase shp 2; protein tyrosine phosphatase, non-receptor type 11; src homology 2 domain-containing tyrosine phosphatase-2 (shp-2); tissue microarray (tma); ptpn11 protein, human |
| Journal Title: | Tumor Biology |
| Volume: | 34 |
| Issue: | 2 |
| ISSN: | 1010-4283 |
| Publisher: | Springer Netherlands |
| Date Published: | 2013-04-01 |
| Start Page: | 637 |
| End Page: | 642 |
| Language: | English |
| DOI: | 10.1007/s13277-012-0590-1 |
| PUBMED: | 23192641 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 19 July 2013" - "CODEN: TUMBE" - "Source: Scopus" |
