Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1 Journal Article
| Authors: | Rubio, M. E.; Curcio, C.; Chauvet, N.; Bruses, J. L. |
| Article Title: | Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1 |
| Abstract: | N-cadherin is an adhesion receptor that participates in both interaction between immature pre- and postsynaptic neurons and in the stabilization and function of matured neuron-neuron synapses. To better understand how the N-cadherin complex contributes to synapse formation, we examined its distribution and composition during synapse formation in the chick ciliary neurons. It was found that at early phases of synaptogenesis, beta-cadherin is distributed in small clusters on the cell surface and primarily associates with p120-catenin and beta-catenin. In contrast, as synaptic contacts matured, larger beta-cadherin clusters were found localized adjacent to the active zone and associated with PSI and gamma-catenin, while p120- and beta-catenin were dispersed among other cell regions, including axons. As it is known that PSI binds gamma-catenin and that uncoupled p120-catenin can alter the cytoskeleton via its effect on Rho GTPases, these changes in the molecular composition of the beta-cadherin complex (represented by the uncoupling of p120-catenin and association with PSI) may correspond to distinct functional states of the complex involved in synaptic maturation. (c) 2005 Elsevier Inc. All rights reserved. |
| Keywords: | synapse formation |
| Journal Title: | Molecular and Cellular Neuroscience |
| Volume: | 30 |
| Issue: | 4 |
| ISSN: | 1044-7431 |
| Publisher: | Academic Press Inc., Elsevier Science |
| Date Published: | 2005-12-01 |
| Start Page: | 611 |
| End Page: | 623 |
| Language: | English |
| DOI: | 10.1016/j.mcn.2005.06.011 |
| ACCESSION: | BIOSIS:PREV200600202894 |
| PROVIDER: | biosis |
| PUBMED: | 16456928 |
| DOI/URL: | |
| Notes: | --- - Article - "Source: Biosis" |
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