Randomized Clinical Trials in Soft Tissue Sarcoma Journal Article
| Authors: | Katz, S. C.; Brennan, M. F. |
| Article Title: | Randomized Clinical Trials in Soft Tissue Sarcoma |
| Abstract: | Soft tissue sarcomas (STS) are rare, but potentially lethal, extraskeletal mesenchymal neoplasms. It is estimated that approximately 12,000 cases of STS are reported annually in the United States, with 3,500 STS deaths. Few randomized controlled trials (RCTs) have been conducted since the previous issue of this publication. The current understanding of STS biology and, hence, ability to provide safe, effective therapy is predicated upon seminal trials performed in the 1980s and 1990s. The authors briefly summarize the trials presented in the previous issue and then critically assess the more recent publications that have addressed the management of STS. © 2010 Elsevier Inc. All rights reserved. |
| Keywords: | cancer chemotherapy; cancer surgery; overall survival; clinical trial; drug tolerability; neutropenia; review; cisplatin; doxorubicin; drug efficacy; drug withdrawal; unspecified side effect; gemcitabine; adjuvant therapy; postoperative care; preoperative care; chemotherapy; drug megadose; recurrent cancer; metastasis; quality of life; controlled clinical trial; multiple cycle treatment; peritoneum cancer; leukopenia; randomized controlled trial; randomized controlled trials as topic; continuous infusion; ifosfamide; high risk patient; docetaxel; febrile neutropenia; sarcoma; brain disease; soft tissue sarcoma; brachytherapy; nausea and vomiting; surgery; epirubicin; radiation therapy; external beam radiotherapy; mesna; alopecia; wound complication; hemorrhagic cystitis; soft-tissue sarcoma; peritoneum sarcomatosis |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 19 |
| Issue: | 1 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-01-01 |
| Start Page: | 1 |
| End Page: | 11 |
| Language: | English |
| DOI: | 10.1016/j.soc.2009.09.006 |
| PUBMED: | 19914557 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: SOCAF" - "Source: Scopus" |
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