Contribution of diet and physical activity to metabolic parameters among survivors of childhood leukemia Journal Article

Authors: Tonorezos, E. S.; Robien, K.; Eshelman-Kent, D.; Moskowitz, C. S.; Church, T. S.; Ross, R.; Oeffinger, K. C.
Article Title: Contribution of diet and physical activity to metabolic parameters among survivors of childhood leukemia
Abstract: Purpose: Determine the relationship between diet and metabolic abnormalities among adult survivors of childhood acute lymphoblastic leukemia (ALL). Methods: We surveyed 117 adult survivors of childhood ALL using the Harvard Food Frequency Questionnaire. Physical activity energy expenditure (PAEE) was measured with the SenseWear Pro2 Armband. Insulin resistance was estimated using the Homeostasis Model for Insulin Resistance (HOMA-IR). Visceral and subcutaneous adiposity were measured by abdominal CT. Adherence to a Mediterranean diet pattern was calculated using the index developed by Trichopoulou. Subjects were compared using multivariate analysis adjusted for age and gender. Results: Greater adherence to a Mediterranean diet pattern was associated with lower visceral adiposity (p = 0.07), subcutaneous adiposity (p < 0.001), waist circumference (p = 0.005), and body mass index (p = 0.04). For each point higher on the Mediterranean Diet Score, the odds of having the metabolic syndrome fell by 31 % (OR 0.69; 95 % CI 0.50, 0.94; p = 0.019). Higher dairy intake was associated with higher HOMA-IR (p = 0.014), but other individual components of the Mediterranean diet, such as low intake of meat or high intake of fruits and vegetables, were not significant. PAEE was not independently associated with metabolic outcomes, although higher PAEE was associated with lower body mass index. Conclusions: Adherence to a Mediterranean diet pattern was associated with better metabolic and anthropometric parameters in this cross-sectional study of ALL survivors. © 2012 Springer Science+Business Media Dordrecht.
Keywords: adolescent; adult; controlled study; leukemia; young adult; major clinical study; outcome assessment; obesity; acute lymphoblastic leukemia; cancer survivor; survivors; diet; body mass; food frequency questionnaire; scoring system; survivorship; precursor cell lymphoblastic leukemia-lymphoma; diastolic blood pressure; insulin resistance; metabolic syndrome x; systolic blood pressure; waist circumference; sex difference; mediterranean diet; physical activity; motor activity; alcohol consumption; childhood leukemia; meat; dairy product; fat intake; intraabdominal fat; energy expenditure; subcutaneous fat; lean body weight; fruit vegetable
Journal Title: Cancer Causes & Control
Volume: 24
Issue: 2
ISSN: 0957-5243
Publisher: Springer  
Date Published: 2013-02-01
Start Page: 313
End Page: 321
Language: English
DOI: 10.1007/s10552-012-0116-6
PROVIDER: scopus
PMCID: PMC3557541
PUBMED: 23187859
Notes: --- - "Export Date: 1 July 2013" - "CODEN: CCCNE" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Chaya S. Moskowitz
    226 Moskowitz
  2. Kevin Oeffinger
    294 Oeffinger