Compact divided-pupil line-scanning confocal microscope for investigation of human tissues Conference Paper
| Authors: | Glazowski, C.; Peterson, G.; Rajadhyaksha, M. |
| Title: | Compact divided-pupil line-scanning confocal microscope for investigation of human tissues |
| Conference Title: | Photonic Therapeutics and Diagnostics IX |
| Abstract: | Divided-pupil line-scanning confocal microscopy (DPLSCM) can provide a simple and low-cost approach for imaging of human tissues with pathology-like nuclear and cellular detail. Using results from a multidimensional numerical model of DPLSCM, we found optimal pupil configurations for improved axial sectioning, as well as control of speckle noise in the case of reflectance imaging. The modeling results guided the design and construction of a simple (10 component) microscope, packaged within the footprint of an iPhone, and capable of cellular resolution. We present the optical design with experimental video-images of in-vivo human tissues. © 2013 SPIE. |
| Keywords: | confocal; microscopy; linescanning; scanning; histology; endoscopy; confocal microscopes; reflectance imaging; tissue; divided-pupil; line-scanning; microscopic examination; speckle; turbid; cellular resolution; design and construction; optical design |
| Journal Title | Proceedings of SPIE |
| Volume: | 8565 |
| Conference Dates: | 2013 Feb 2-7 |
| Conference Location: | San Francisco, CA |
| ISBN: | 0277-786X |
| Publisher: | SPIE |
| Location: | San Francisco, CA |
| Date Published: | 2013-01-01 |
| Start Page: | 856523 |
| Language: | English |
| PROVIDER: | scopus |
| DOI: | 10.1117/12.2012630 |
| DOI/URL: | |
| Notes: | --- - Progress in Biomedical Optics and Imaging - Proceedings of SPIE - Progr. Biomed. Opt. Imaging Proc. SPIE - "Conference code: 97149" - "Export Date: 1 July 2013" - ":doi 10.1117/12.2012630" - "Sponsors: The Society of Photo-Optical Instrumentation Engineers (SPIE)" - 2 February 2013 through 7 February 2013 - "Source: Scopus" |
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