Neuroblastoma: Developmental biology, cancer genomics and immunotherapy Journal Article
| Authors: | Cheung, N. K. V.; Dyer, M. A. |
| Article Title: | Neuroblastoma: Developmental biology, cancer genomics and immunotherapy |
| Abstract: | Neuroblastoma is a solid tumour that arises from the developing sympathetic nervous system. Over the past decade, our understanding of this disease has advanced tremendously. The future challenge is to apply the knowledge gained to developing risk-based therapies and, ultimately, improving outcome. In this Review we discuss the key discoveries in the developmental biology, molecular genetics and immunology of neuroblastoma, as well as new translational tools for bringing these promising scientific advances into the clinic. © 2013 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | signal transduction; cancer survival; gene mutation; overall survival; review; cancer risk; cell proliferation; cancer immunotherapy; gene amplification; developmental biology; angiogenesis; monoclonal antibody; cancer genetics; regulatory t lymphocyte; cellular immunity; neuroblastoma; ganglioside gd2; natural killer cell; chromosomal instability; familial cancer; neural crest; beta glucan; nerve cell differentiation; energy metabolism; granulocyte; cancer immunology; tumor invasion |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 13 |
| Issue: | 6 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2013-06-01 |
| Start Page: | 397 |
| End Page: | 411 |
| Language: | English |
| DOI: | 10.1038/nrc3526 |
| PROVIDER: | scopus |
| PUBMED: | 23702928 |
| PMCID: | PMC4386662 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 July 2013" - "CODEN: NRCAC" - "Source: Scopus" |
