The lessons of QUANTEC: Recommendations for reporting and gathering data on dose-volume dependencies of treatment outcome Journal Article

   


Authors: Jackson, A.; Marks, L. B.; Bentzen, S. M.; Eisbruch, A.; Yorke, E. D.; Ten Haken, R. K.; Constine, L. S.; Deasy, J. O.
Article Title: The lessons of QUANTEC: Recommendations for reporting and gathering data on dose-volume dependencies of treatment outcome
Abstract: The 16 clinical articles in this issue review the dose-volume dependence of toxicities of external beam radiotherapy. They are limited by the difficulty of synthesizing results from different publications. The major problems stem from incomplete reporting of results and use of incompatible or ambiguous endpoints. Here we specify these problems; give recommendations to authors, editors, and reviewers on standards of reporting; and provide methods of defining endpoints suitable for the dose-volume analysis of toxicity. Adopting these recommendations will facilitate meta-analysis and increase the utility of individual studies of the dependence of complications on dose distributions. © 2010 Elsevier Inc. All rights reserved.
Keywords: treatment outcome; cancer radiotherapy; radiation dose; clinical practice; radiotherapy; radiation injury; radiation response; dose-response relationship, radiation; hospitalization; quantitative analysis; radiation injuries; rating scale; meta-analysis as topic; external beam radiotherapy; toxicity; organ size; radiation dose distribution; radiation pneumonia; histogram; standards; meta-analysis; treatment outcomes; dose distributions; dose-volume analysis; dose-volume; endpoint definition; normal tissue toxicity; statistical reporting standards; statistical reporting
Journal Title: International Journal of Radiation Oncology, Biology, Physics
Volume: 76
Issue: 3 Suppl.
ISSN: 0360-3016
Publisher: Elsevier Inc.  
Date Published: 2010-03-01
Start Page: S155
End Page: S160
Language: English
DOI: 10.1016/j.ijrobp.2009.08.074
PUBMED: 20171512
PROVIDER: scopus
PMCID: PMC2854159
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-76449087147&partnerID=40&md5=4ffc77005b1ce302b452078cc68c64f8
Notes: --- - "Cited By (since 1996): 2" - "Export Date: 20 April 2011" - "CODEN: IOBPD" - "Source: Scopus"
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MSK Authors
  1. Andrew Jackson
    253 Jackson
  2. Ellen D Yorke
    450 Yorke
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