The atlas of complication incidence: A proposal for a new standard for reporting the results of radiotherapy protocols Journal Article
| Authors: | Jackson, A.; Yorke, E. D.; Rosenzweig, K. E. |
| Article Title: | The atlas of complication incidence: A proposal for a new standard for reporting the results of radiotherapy protocols |
| Abstract: | We present a new method of reporting the results of radiotherapy protocols. The dose-volume atlas of complication incidence is a comprehensive and unbiased summary of the dose-volume exposures and complications occurring in patients after treatment. This new tool provides clear and systematic information about the safety of regions of dose-volume exposure previously treated that can be used when considering new treatments. Actuarial and model-dependent versions of the atlas are described. By using the raw data in the appropriate forms of the atlas, logistic regression, Kaplan-Meier, and Cox proportional hazards analysis can be performed, allowing for the independent calculation of dose-volume response. The data required are simple enough that provided compatible definitions of dose, volume, and complications are used, atlases from different protocols are potentially additive, facilitating the meta-analysis of inter-interinstitutional data. If this method were adopted as a standard for reporting the outcome of treatment protocols, a potentially synergistic increase in the utility of each protocol could result. © 2006 Elsevier Inc. All rights reserved. |
| Keywords: | dose response; outcome assessment; neoplasms; radiotherapy dosage; radiotherapy; incidence; risk assessment; pneumonia; statistical analysis; clinical protocols; radiation injuries; kaplan meier method; urogenital system; logistic regression analysis; standards; atlas; complication incidence; digestive system; dvh; reporting outcome |
| Journal Title: | Seminars in Radiation Oncology |
| Volume: | 16 |
| Issue: | 4 |
| ISSN: | 1053-4296 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2006-10-01 |
| Start Page: | 260 |
| End Page: | 268 |
| Language: | English |
| DOI: | 10.1016/j.semradonc.2006.04.009 |
| PUBMED: | 17010909 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 10" - "Export Date: 4 June 2012" - "CODEN: SRONE" - "Source: Scopus" |
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450Yorke
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