B-cell tolerance checkpoints in healthy humans and patients with systemic lupus erythematosus Conference Paper
| Authors: | Yurasov, S.; Hammersen, J.; Tiller, T.; Tsuiji, M.; Wardemann, H. |
| Title: | B-cell tolerance checkpoints in healthy humans and patients with systemic lupus erythematosus |
| Conference Title: | Human Immunology: Patient-Based Research |
| Abstract: | Antibodies are protective effector molecules in the body's immune defense against pathogens. However, if directed against the body's own tissues or organs, antibodies can also play a role in the pathogenesis of autoimmune disease. Here, we discuss our data on how autoreactive antibodies are regulated in healthy humans and how a failure to establish self-tolerance during early B-cell development in patients with systemic lupus erythematosus may predispose to the development of this autoimmune disease. |
| Keywords: | autoimmunity; antibodies; autoantibody; transgenic mice; tolerance; receptors; rearrangements; b cell; lambda; autoimmune-diseases; escape tolerance; sle; light-chain gene; variable-region; autoantibody production |
| Journal Title | Annals of the New York Academy of Sciences |
| Volume: | 1062 |
| Conference Dates: | 2005 May 16-18 |
| Conference Location: | New York, NY |
| ISBN: | 0077-8923 |
| Publisher: | John Wiley & Sons |
| Location: | New York |
| Date Published: | 2005-12-01 |
| Start Page: | 165 |
| End Page: | 174 |
| Language: | English |
| ACCESSION: | WOS:000236473100017 |
| PROVIDER: | wos |
| PUBMED: | 16461799 |
| DOI: | 10.1196/annals.1358.019 |
| Notes: | --- - Article; Proceedings Paper in "Human Immunology: Patient-Based Research" - Conference on Human Immunology - MAY 16-18, 2005 - New York, NY - NY Acad Sci, Dana Fdn - 2 EAST 63RD ST, NEW YORK, NY 10021 USA - "Source: Wos" |
