Targeting brain cancer: Advances in the molecular pathology of malignant glioma and medulloblastoma Journal Article
| Authors: | Huse, J. T.; Holland, E. C. |
| Article Title: | Targeting brain cancer: Advances in the molecular pathology of malignant glioma and medulloblastoma |
| Abstract: | Malignant brain tumours continue to be the cause of a disproportionate level of morbidity and mortality across a wide range of individuals. The most common variants in the adult and paediatric populations malignant glioma and medulloblastoma, respectively have been the subject of increasingly intensive research over the past two decades that has led to considerable advances in the understanding of their basic biology and pathogenesis. This Review summarizes these developments in the context of the evolving notion of molecular pathology and discusses the implications that this work has on the design of new treatment regimens. © 2010 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | signal transduction; mitogen activated protein kinase; gene mutation; review; nonhuman; glioma; brain neoplasms; cancer grading; animals; gene expression profiling; molecular dynamics; genetic transcription; pathology; protein tyrosine kinase; phosphatidylinositol 3 kinase; protein p53; cancer therapy; morphology; gene expression regulation; glioblastoma; mammalian target of rapamycin; medulloblastoma; cancer stem cell; ras protein; brain cancer; comparative genomic hybridization; wnt protein; cerebellar neoplasms; oncogene ras; pathology, molecular; turcot syndrome |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 10 |
| Issue: | 5 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2010-05-01 |
| Start Page: | 319 |
| End Page: | 331 |
| Language: | English |
| DOI: | 10.1038/nrc2818 |
| PUBMED: | 20414201 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 17" - "Export Date: 20 April 2011" - "CODEN: NRCAC" - "Source: Scopus" |
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