Stem cell model of hematologic diseases Book Section

  


Author: Abdel-Wahab, O.
Editors: Hoffman, R.; Benz, E. J. Jr; Silberstein, L. E.; Heslop, H. E.; Weitz, J. I.; Salama, M. E.; Abutalib, S. A.
Article/Chapter Title: Stem cell model of hematologic diseases
Abstract: One of the prevailing models of cancer development proposes that a cancer is initiated and maintained through the function of cancer stem cells (CSCs), which represent a rare population of cells within a cancer that have an indefinite proliferative potential and are ultimately responsible for the generation of the bulk of cancer cells. This so-called CSC hypothesis has been best studied in hematopoietic malignancies. While identification of a single normal hematopoietic cell subset as the target of the malignant transformation and the cellular reservoir for disease has been possible for a variety of myeloid leukemias and lymphomas, pinpointing a single cell as the target of malignant transformation has not yet proven possible for other hematopoietic malignancies. In this chapter, we discuss efforts to identify the malignant stem cell for each of the common forms of myeloid and lymphoid malignancies. © 2023 by Elsevier Inc. All rights reserved.
Keywords: cancer stem cell; stem cells; hematopoietic stem cell; leukemic stem cells; clonal hematopoiesis; leukemia-initiating cell; myeloid progenitors; monoclonal b lymphocytosis
Book Title: Hematology: Basic Principles and Practice. 8th ed
ISBN: 978-032373388-5
Publisher: Elsevier Inc.  
Publication Place: Philadelphia, PA
Date Published: 2023-01-01
Start Page: 149
End Page: 156
Language: English
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-105000581334&doi=10.1016%2fB978-0-323-73388-5.00013-4&partnerID=40&md5=a62c03d9f53574f04197fa649e8ee00e
Notes: Book chapter: 13 -- Source: Scopus