Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation Journal Article

   

Authors:	Moran-Crusio, K.; Reavie, L.; Shih, A.; Abdel-Wahab, O.; Ndiaye-Lobry, D.; Lobry, C.; Figueroa, M.; Vasanthakumar, A.; Patel, J.; Zhao, X.; Perna, F.; Pandey, S.; Madzo, J.; Song, C.; Dai, Q.; He, C.; Ibrahim, S.; Beran, M.; Zavadil, J.; Nimer, S.; Melnick, A.; Godley, L.; Aifantis, I.; Levine, R.
Article Title:	Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
Abstract:	Somatic loss-of-function mutations in the ten-eleven translocation 2 (TET2) gene occur in a significant proportion of patients with myeloid malignancies. Although there are extensive genetic data implicating TET2 mutations in myeloid transformation, the consequences of Tet2 loss in hematopoietic development have not been delineated. We report here an animal model of conditional Tet2 loss in the hematopoietic compartment that leads to increased stem cell self-renewal in vivo as assessed by competitive transplant assays. Tet2 loss leads to a progressive enlargement of the hematopoietic stem cell compartment and eventual myeloproliferation in vivo, including splenomegaly, monocytosis, and extramedullary hematopoiesis. In addition, Tet2+/- mice also displayed increased stem cell self-renewal and extramedullary hematopoiesis, suggesting that Tet2 haploinsufficiency contributes to hematopoietic transformation in vivo. © 2011 Elsevier Inc.
Journal Title:	Cancer Cell
Volume:	20
Issue:	1
ISSN:	1535-6108
Publisher:	Cell Press
Date Published:	2011-07-12
Start Page:	11
End Page:	24
Language:	English
DOI:	10.1016/j.ccr.2011.06.001
PROVIDER:	scopus
PUBMED:	21723200
PMCID:	PMC3194039
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-79960064353&partnerID=40&md5=ca356c55998cbdf0848ed38e1beb5dd0
Notes:	--- - "Export Date: 17 August 2011" - "CODEN: CCAEC" - "Source: Scopus"

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